Abstract：
Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA other than surgery. The exploration of the mechanisms of occurrence is important in exploring other new and effective treatments for OA. The current evidence shows that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays a vital role in cytogenesis and is involved in OA progression. The terms \"JAK2\", \"STAT3\", and \"Osteoarthritis\"were used in a comprehensive literature search in PubMed to further investigate the relationship between the JAK2/STAT3 signaling pathway and OA. This review focuses on the role and mechanism of JAK2/STAT3 signaling in cartilage degradation, subchondral bone dysfunction, and synovial inflammation. In addition, this review summarizes recent evidence of therapeutic approaches to treat OA by targeting the JAK2/STAT3 pathway to accelerate the translation of evidence into the progression of strategies for OA treatment. Video abstract.
摘要：
骨关节炎（OA）是一种多因素慢性疾病，主要特征在于关节软骨的变性。目前,除手术外，OA缺乏有效的治疗方法。探索其发生机制对于探索其他新的有效治疗OA具有重要意义。目前的证据表明，Janus激酶2（JAK2）/信号转导和转录激活因子3（STAT3）信号通路在细胞发生中起着至关重要的作用，并参与OA的进展。术语“JAK2”，\"STAT3\",和“骨关节炎”在PubMed中进行了全面的文献检索，以进一步研究JAK2/STAT3信号通路与OA之间的关系。本文就JAK2/STAT3信号通路在软骨降解中的作用及机制进行综述。软骨下骨功能障碍，和滑膜炎.此外,这篇综述总结了通过靶向JAK2/STAT3通路来加速证据转化为OA治疗策略进展的治疗方法的最新证据.视频摘要。
