Abstract：
The role of maternal age in the development of non-chromosomal congenital anomalies (NCAs) is under debate. Therefore, the primary aim of this study was to identify the age groups at risk for NCAs. The secondary aim was to perform a detailed analysis of the relative frequency of various anomalies.
National population-based study.
The Hungarian Case-Control Surveillance of Congenital Anomalies (CAs) between 1980 and 2009.
A cohort of 31 128 cases with confirmed NCAs was compared with Hungary\'s total of 2 808 345 live births.
Clinicians prospectively reported cases after delivery. Data were analysed by non-linear logistic regression. Risk-increasing effect of young and advanced maternal age was determined by each NCA group.
These were the total number of NCAs: cleft lip and palate, circulatory, genital, musculoskeletal, digestive, urinary, eye, ear, face, and neck, nervous system, and respiratory system anomalies.
The occurrence of NCAs in our database was lowest between 23 and 32 years of maternal age at childbirth. The relative risk (RR) of any NCA was 1.2 (95% CI 1.17-1.23) and 1.15 (95% CI 1.11-1.19) in the very young and advanced age groups, respectively. The respective results for the circulatory system were RR = 1.07 (95% CI 1.01-1.13) and RR = 1.33 (95% CI 1.24-1.42); for cleft lip and palate RR = 1.09 (95% CI 1.01-1.19) and RR = 1.45 (95% CI 1.26-1.67); for genital organs RR = 1.15 (95% CI 1.08-1.22) and RR = 1.16 (95% CI 1.04-1.29); for the musculoskeletal system RR = 1.17 (95% CI 1.12-1.23) and RR = 1.29 (95% CI 1.14-1.44); and for the digestive system RR = 1.23 (95% CI 1.14-1.31) and RR = 1.16 (95% CI 1.04-1.29).
Very young and advanced maternal ages are associated with different types of NCAs. Therefore, screening protocols should be adjusted for these risk groups.
National population-based study.
The Hungarian Case-Control Surveillance of Congenital Anomalies (CAs) between 1980 and 2009.
A cohort of 31 128 cases with confirmed NCAs was compared with Hungary\'s total of 2 808 345 live births.
Clinicians prospectively reported cases after delivery. Data were analysed by non-linear logistic regression. Risk-increasing effect of young and advanced maternal age was determined by each NCA group.
These were the total number of NCAs: cleft lip and palate, circulatory, genital, musculoskeletal, digestive, urinary, eye, ear, face, and neck, nervous system, and respiratory system anomalies.
The occurrence of NCAs in our database was lowest between 23 and 32 years of maternal age at childbirth. The relative risk (RR) of any NCA was 1.2 (95% CI 1.17-1.23) and 1.15 (95% CI 1.11-1.19) in the very young and advanced age groups, respectively. The respective results for the circulatory system were RR = 1.07 (95% CI 1.01-1.13) and RR = 1.33 (95% CI 1.24-1.42); for cleft lip and palate RR = 1.09 (95% CI 1.01-1.19) and RR = 1.45 (95% CI 1.26-1.67); for genital organs RR = 1.15 (95% CI 1.08-1.22) and RR = 1.16 (95% CI 1.04-1.29); for the musculoskeletal system RR = 1.17 (95% CI 1.12-1.23) and RR = 1.29 (95% CI 1.14-1.44); and for the digestive system RR = 1.23 (95% CI 1.14-1.31) and RR = 1.16 (95% CI 1.04-1.29).
Very young and advanced maternal ages are associated with different types of NCAs. Therefore, screening protocols should be adjusted for these risk groups.
摘要：
目的：产妇年龄在非染色体先天性异常（NCA）发展中的作用正在争论中。因此,本研究的主要目的是确定有NCA风险的年龄组.次要目的是对各种异常的相对频率进行详细分析。
方法：全国基于人群的研究。
方法：1980年至2009年匈牙利先天性异常（CA）病例对照监测。
方法：将31128例确诊NCA的队列与匈牙利的2808345例活产进行了比较。
方法：临床医生前瞻性报道分娩后的病例。数据采用非线性逻辑回归分析。每个NCA组确定了年轻和高龄产妇的风险增加效应。
方法：这些是NCA的总数：唇腭裂，循环,生殖器,肌肉骨骼，消化性,泌尿,眼睛,耳朵,脸,脖子,神经系统,呼吸系统异常.
结果：在我们的数据库中，NCA的发生率在23至32岁的产妇分娩时最低。在非常年轻和高龄的年龄组中，任何NCA的相对风险（RR）分别为1.2（95％CI1.17-1.23）和1.15（95％CI1.11-1.19），分别。循环系统的相应结果为RR=1.07（95％CI1.01-1.13）和RR=1.33（95％CI1.24-1.42）；对于唇裂和腭裂，RR=1.09（95％CI1.01-1.19）和RR=1.45（95％CI1.26-1.67）；对于生殖器官RR=1.15（95％CI1.08-1.14）和1.14（95-1.14RR=1.
结论：非常年轻和高龄的母亲与不同类型的NCA相关。因此,应针对这些风险组调整筛查方案.
方法：全国基于人群的研究。
方法：1980年至2009年匈牙利先天性异常（CA）病例对照监测。
方法：将31128例确诊NCA的队列与匈牙利的2808345例活产进行了比较。
方法：临床医生前瞻性报道分娩后的病例。数据采用非线性逻辑回归分析。每个NCA组确定了年轻和高龄产妇的风险增加效应。
方法：这些是NCA的总数：唇腭裂，循环,生殖器,肌肉骨骼，消化性,泌尿,眼睛,耳朵,脸,脖子,神经系统,呼吸系统异常.
结果：在我们的数据库中，NCA的发生率在23至32岁的产妇分娩时最低。在非常年轻和高龄的年龄组中，任何NCA的相对风险（RR）分别为1.2（95％CI1.17-1.23）和1.15（95％CI1.11-1.19），分别。循环系统的相应结果为RR=1.07（95％CI1.01-1.13）和RR=1.33（95％CI1.24-1.42）；对于唇裂和腭裂，RR=1.09（95％CI1.01-1.19）和RR=1.45（95％CI1.26-1.67）；对于生殖器官RR=1.15（95％CI1.08-1.14）和1.14（95-1.14RR=1.
结论：非常年轻和高龄的母亲与不同类型的NCA相关。因此,应针对这些风险组调整筛查方案.
