Abstract：
UNASSIGNED: To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.
UNASSIGNED: In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators, and serum serine levels of the two groups were compared to analyze the influencing factors of HI.
UNASSIGNED: The age and d-serine levels were higher in the HI group, while the l-serine level was lower than uremia in the normal hearing group. Logistic regression analysis showed that d-serine level ≥10 μM and older age increased the risk of HI. The area of the receiver operating characteristic (ROC) curve drawn by the prediction probability of HI was 0.838, indicating that age, d-serine, and l-serine had predictive diagnostic values for HI (p < .001). Among these, the ROC curve area of d-serine in predicting HI in uremic patients was 0.822 (p < .001).
UNASSIGNED: Increased d-serine and age are two risk factors for HI, while l-serine is a protective factor. d-Serine level has a predictive value for HI in uremic patients. Uremic patients are recommended hearing assessment, estimation of d-serine levels, and early intervention.
UNASSIGNED: In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators, and serum serine levels of the two groups were compared to analyze the influencing factors of HI.
UNASSIGNED: The age and d-serine levels were higher in the HI group, while the l-serine level was lower than uremia in the normal hearing group. Logistic regression analysis showed that d-serine level ≥10 μM and older age increased the risk of HI. The area of the receiver operating characteristic (ROC) curve drawn by the prediction probability of HI was 0.838, indicating that age, d-serine, and l-serine had predictive diagnostic values for HI (p < .001). Among these, the ROC curve area of d-serine in predicting HI in uremic patients was 0.822 (p < .001).
UNASSIGNED: Increased d-serine and age are two risk factors for HI, while l-serine is a protective factor. d-Serine level has a predictive value for HI in uremic patients. Uremic patients are recommended hearing assessment, estimation of d-serine levels, and early intervention.
摘要：
■探讨血清d-丝氨酸水平对尿毒症患者听力损害（HI）的预测价值。
■在这项研究中，选择HI尿毒症患者30例，听力正常30例。基本条件,生化指标,比较两组血清丝氨酸水平,分析HI的影响因素。
■HI组的年龄和d-丝氨酸水平较高，而正常听力组的l-丝氨酸水平低于尿毒症。Logistic回归分析显示,d-丝氨酸水平≥10μM及年龄增加HI风险。HI预测概率绘制的受试者工作特征(ROC)曲线面积为0.838,表明年龄、d-丝氨酸,和l-丝氨酸对HI具有预测诊断价值（p<.001）。其中,d-丝氨酸预测尿毒症患者HI的ROC曲线面积为0.822(p<.001)。
■d-丝氨酸增加和年龄是HI的两个危险因素，而l-丝氨酸是一种保护因子。d-丝氨酸水平对尿毒症患者的HI具有预测价值。建议尿毒症患者进行听力评估，d-丝氨酸水平的估计，早期干预。
■在这项研究中，选择HI尿毒症患者30例，听力正常30例。基本条件,生化指标,比较两组血清丝氨酸水平,分析HI的影响因素。
■HI组的年龄和d-丝氨酸水平较高，而正常听力组的l-丝氨酸水平低于尿毒症。Logistic回归分析显示,d-丝氨酸水平≥10μM及年龄增加HI风险。HI预测概率绘制的受试者工作特征(ROC)曲线面积为0.838,表明年龄、d-丝氨酸,和l-丝氨酸对HI具有预测诊断价值（p<.001）。其中,d-丝氨酸预测尿毒症患者HI的ROC曲线面积为0.822(p<.001)。
■d-丝氨酸增加和年龄是HI的两个危险因素，而l-丝氨酸是一种保护因子。d-丝氨酸水平对尿毒症患者的HI具有预测价值。建议尿毒症患者进行听力评估，d-丝氨酸水平的估计，早期干预。
