PDF(Pubmed)
Abstract：
Bietti crystalline dystrophy is a rare hereditary autosomal recessive disease that causes photoreceptor loss secondary to degeneration of retinal pigment epithelium due to intracellular retinal pigment epithelial crystalline deposits and abnormal lipid metabolism. We aimed to present a case of choroidal neovascular membrane secondary to Bietti crystalline dystrophy diagnosed with multimodal imaging and treated with an intravitreal injection of aflibercept. A single dose of aflibercept injection might be effective due to its higher affinity for vascular endothelial growth factor (VEGF) in comparison with other anti-VEGFs. It might be a treatment alternative that can be considered in the choroidal neovascular membrane due to uncommon etiologies.
摘要：
Bietti晶体营养不良是一种罕见的遗传性常染色体隐性遗传疾病，由于细胞内视网膜色素上皮晶体沉积和异常的脂质代谢，导致继发性视网膜色素上皮变性的光感受器丧失。我们的目的是介绍一例继发于Bietti晶体营养不良的脉络膜新生血管膜，该病例通过多模式成像诊断并接受玻璃体内注射阿柏西普治疗。与其他抗VEGF相比，单剂量的阿柏西普注射液可能是有效的，因为它对血管内皮生长因子（VEGF）的亲和力更高。由于不常见的病因，可能是脉络膜新生血管膜中可以考虑的治疗替代方法。
