Abstract：
A single bout of cardiovascular exercise can have a cascade of physiological effects, including increased blood flow to the brain. This effect has been documented across multiple modalities, yet studies have reported mixed findings. Here, we systematically review evidence for the acute effect of cardiovascular exercise on cerebral blood flow across a range of neuroimaging techniques and exercise characteristics. Based on 52 studies and a combined sample size of 1,174 individuals, our results indicate that the acute effect of cardiovascular exercise on cerebral blood flow generally follows an inverted U-shaped relationship, whereby blood flow increases early on but eventually decreases as exercise continues. However, we also find that this effect is not uniform across studies, instead varying across a number of key variables including exercise characteristics, brain regions, and neuroimaging modalities. As the most comprehensive synthesis on the topic to date, this systematic review sheds light on the determinants of exercise-induced change in cerebral blood flow, a necessary step toward personalized interventions targeting brain health across a range of populations.
摘要：
一次心血管运动可以产生一连串的生理效应，包括增加大脑的血流量.这种影响已经在多种模式中得到了记录，然而，研究报告的结果好坏参半。这里,我们系统地回顾了心血管运动对一系列神经影像学技术和运动特征的脑血流急性影响的证据.根据52项研究和1174名个体的综合样本量，我们的结果表明，心血管运动对脑血流量的急性影响通常遵循倒U型关系，血流量早期增加，但随着运动的继续，最终减少。然而,我们还发现这种效果在研究中并不一致，相反，在包括锻炼特征在内的许多关键变量之间存在差异，大脑区域,和神经成像模式。作为迄今为止关于该主题的最全面的综合，这篇系统的综述揭示了运动引起的脑血流量变化的决定因素，朝着针对一系列人群的大脑健康的个性化干预迈出了必要的一步。
