Abstract：
BACKGROUND: Nevus comedonicus (NC) is a rare cutaneous disorder thought to be caused by hamartomatous pilosebaceous tissue proliferation that was first described in 1895. Clinically NC appears as a group of elevated follicular openings often linearly arrayed, giving the appearance of comedones. NC usually manifests at birth but can also present later during adolescence and rarely in adulthood.
METHODS: A 21-year-old medically healthy single male presented with right-sided chest black papules in comedo distribution with areas of superficial ulcerations and suppurations in periareolar distribution since the age of 16. Histopathological examination showed dilated follicular ostia filled with keratin plug, devoid of the hair shaft, and lined by stratified squamous epithelium with compact hyperkeratosis, focal parakeratosis, and patchy atrophy and acanthosis.
UNASSIGNED: Nevus comedonicus often responds effectively to conservative treatment, however some cases need surgery intervention. The patient failed conservative medical and topical treatment, and he was treated by surgical-wide local excision and primary closure of the affected skin with free nipple grafting.
CONCLUSIONS: Nevus comedonicus (NC) is a rare cutaneous pathology secondary to pilosebaceous apparatus developmental defect that usually manifests at birth and can affect any area of skin; they typically manifest as black papules in comedo distribution. They can present as an isolated cutaneous pathology or as a component of nevus comedonicus syndrome. Different therapeutic approaches were described, including topical retinoids, keratolytic agents, oral retinoids, antibiotic therapy, manual extraction of comedos, dermabrasion, and surgical resection of the lesion.
METHODS: A 21-year-old medically healthy single male presented with right-sided chest black papules in comedo distribution with areas of superficial ulcerations and suppurations in periareolar distribution since the age of 16. Histopathological examination showed dilated follicular ostia filled with keratin plug, devoid of the hair shaft, and lined by stratified squamous epithelium with compact hyperkeratosis, focal parakeratosis, and patchy atrophy and acanthosis.
UNASSIGNED: Nevus comedonicus often responds effectively to conservative treatment, however some cases need surgery intervention. The patient failed conservative medical and topical treatment, and he was treated by surgical-wide local excision and primary closure of the affected skin with free nipple grafting.
CONCLUSIONS: Nevus comedonicus (NC) is a rare cutaneous pathology secondary to pilosebaceous apparatus developmental defect that usually manifests at birth and can affect any area of skin; they typically manifest as black papules in comedo distribution. They can present as an isolated cutaneous pathology or as a component of nevus comedonicus syndrome. Different therapeutic approaches were described, including topical retinoids, keratolytic agents, oral retinoids, antibiotic therapy, manual extraction of comedos, dermabrasion, and surgical resection of the lesion.
摘要：
背景：粉刺痣（NC）是一种罕见的皮肤疾病，被认为是由错构瘤毛囊皮脂腺组织增生引起的，最早于1895年被描述。临床上，NC表现为一组升高的卵泡开口，通常呈线性排列，给出粉刺的外观。NC通常在出生时出现，但也可以在青春期后期出现，很少在成年期出现。
方法：一名21岁医学健康的单身男性，自16岁起出现粉刺分布的右侧胸部黑色丘疹，乳晕周围分布的浅表溃疡和化脓区域。组织病理学检查显示，扩张的滤泡口充满角蛋白塞，没有毛干，由分层的鳞状上皮衬砌，伴有致密的角化过度，局灶性角化不全,还有斑片状萎缩和棘皮病.
■灰痣通常对保守治疗有有效反应，然而有些病例需要手术干预。患者保守治疗和局部治疗失败，他接受了全手术局部切除和受影响皮肤的初次闭合，并进行了免费乳头移植术。
结论：粉刺痣（NC）是一种罕见的继发于毛囊皮脂腺器官发育缺陷的皮肤病理，通常在出生时表现为并可影响皮肤的任何区域；它们通常在粉刺分布中表现为黑色丘疹。它们可以表现为孤立的皮肤病理学或粉针痣综合征的组成部分。描述了不同的治疗方法，包括外用类维生素A,角质层分离剂，口服类维生素A,抗生素治疗,手工提取喜剧，磨皮术,手术切除病灶.
方法：一名21岁医学健康的单身男性，自16岁起出现粉刺分布的右侧胸部黑色丘疹，乳晕周围分布的浅表溃疡和化脓区域。组织病理学检查显示，扩张的滤泡口充满角蛋白塞，没有毛干，由分层的鳞状上皮衬砌，伴有致密的角化过度，局灶性角化不全,还有斑片状萎缩和棘皮病.
■灰痣通常对保守治疗有有效反应，然而有些病例需要手术干预。患者保守治疗和局部治疗失败，他接受了全手术局部切除和受影响皮肤的初次闭合，并进行了免费乳头移植术。
结论：粉刺痣（NC）是一种罕见的继发于毛囊皮脂腺器官发育缺陷的皮肤病理，通常在出生时表现为并可影响皮肤的任何区域；它们通常在粉刺分布中表现为黑色丘疹。它们可以表现为孤立的皮肤病理学或粉针痣综合征的组成部分。描述了不同的治疗方法，包括外用类维生素A,角质层分离剂，口服类维生素A,抗生素治疗,手工提取喜剧，磨皮术,手术切除病灶.
