Abstract：
UNASSIGNED: Fournier\'s gangrene is a necrotizing infection of the external genitalia, perineal or perianal regions and is mainly seen in males. Its main risk factors include diabetes, chronic alcoholism, HIV and other immune-compromised states. Fournier\'s gangrene has an aggressive course associated with a mortality rate of 20%-30%, making early diagnosis and management very important. The Fournier Gangrene Severity Index (FGSI) has been traditionally used to predict the severity and prognosis. More recently, simplified FGSI (sFGSI) has been proposed and is helpful. However, timely diagnosis, supportive medical management and complete surgical debridement are still the cornerstones of treatment. These must be complemented with early and timely re-look debridements and appropriate reconstruction to cover soft tissue defects. This literature review aims to look at recent relevant research regards risk factors and prognostic features of Fournier\'s gangrene.
UNASSIGNED: A search was conducted on Google Scholar and PubMed databases for all articles related to Fournier\'s Gangrene. These included clinical reviews, case reports, case series and retrospective studies. Reports or studies which were not published in English were not reviewed. Various reconstructive techniques to cover the defects have also been revisited.
UNASSIGNED: Broad-spectrum antibiotics and urgent surgical debridement are the core management principles of Fournier\'s gangrene. Repeat debridement after 24 h is also recommended. Adjunctive therapies such as hyperbaric oxygen and vacuum-assisted closure are supported in most aspects of recent literature. Expectedly, there is a lack of randomised controlled studies in such emergency surgical conditions, which limits the widespread use of newer therapies to patients unresponsive to conventional management.
UNASSIGNED: Fournier\'s gangrene is a urological emergency with a high mortality rate. The aggressive nature of the infection necessitates early recognition and immediate surgical intervention. Negative pressure dressing and occasional hyperbaric oxygen as adjuncts should be used more routinely, especially if there is a delayed response to conventional treatment or in severe infections.
UNASSIGNED: A search was conducted on Google Scholar and PubMed databases for all articles related to Fournier\'s Gangrene. These included clinical reviews, case reports, case series and retrospective studies. Reports or studies which were not published in English were not reviewed. Various reconstructive techniques to cover the defects have also been revisited.
UNASSIGNED: Broad-spectrum antibiotics and urgent surgical debridement are the core management principles of Fournier\'s gangrene. Repeat debridement after 24 h is also recommended. Adjunctive therapies such as hyperbaric oxygen and vacuum-assisted closure are supported in most aspects of recent literature. Expectedly, there is a lack of randomised controlled studies in such emergency surgical conditions, which limits the widespread use of newer therapies to patients unresponsive to conventional management.
UNASSIGNED: Fournier\'s gangrene is a urological emergency with a high mortality rate. The aggressive nature of the infection necessitates early recognition and immediate surgical intervention. Negative pressure dressing and occasional hyperbaric oxygen as adjuncts should be used more routinely, especially if there is a delayed response to conventional treatment or in severe infections.
摘要：
■Fournier坏疽是外生殖器的坏死性感染，会阴或肛周区域，主要见于男性。其主要危险因素包括糖尿病,慢性酒精中毒,艾滋病毒和其他免疫受损状态。Fournier的坏疽具有与20%-30%的死亡率相关的侵袭性过程，早期诊断和管理非常重要。Fournier坏疽严重程度指数（FGSI）传统上用于预测严重程度和预后。最近,简化的FGSI(sFGSI)已经被提出并且是有帮助的。然而,及时诊断,支持性医疗管理和完整的手术清创仍然是治疗的基石。这些必须通过早期和及时的清创和适当的重建来补充，以覆盖软组织缺损。这篇文献综述旨在回顾最近有关Fournier坏疽的危险因素和预后特征的相关研究。
在GoogleScholar和PubMed数据库中搜索了与FournierGangrene相关的所有文章。这些包括临床审查，病例报告,病例系列和回顾性研究。没有以英文发表的报告或研究没有被审查。还重新讨论了覆盖缺陷的各种重建技术。
■广谱抗生素和紧急手术清创是Fournier坏疽的核心管理原则。也建议在24小时后重复清创。最近文献的大多数方面都支持诸如高压氧和真空辅助闭合之类的辅助疗法。期望,在这种紧急手术条件下缺乏随机对照研究，这限制了对常规管理无反应的患者广泛使用新疗法。
■Fournier坏疽是一种泌尿外科急症，死亡率很高。感染的侵袭性需要早期识别和立即手术干预。应更常规地使用负压敷料和偶尔使用高压氧作为辅助手段，特别是如果对常规治疗或严重感染有延迟反应。
在GoogleScholar和PubMed数据库中搜索了与FournierGangrene相关的所有文章。这些包括临床审查，病例报告,病例系列和回顾性研究。没有以英文发表的报告或研究没有被审查。还重新讨论了覆盖缺陷的各种重建技术。
■广谱抗生素和紧急手术清创是Fournier坏疽的核心管理原则。也建议在24小时后重复清创。最近文献的大多数方面都支持诸如高压氧和真空辅助闭合之类的辅助疗法。期望,在这种紧急手术条件下缺乏随机对照研究，这限制了对常规管理无反应的患者广泛使用新疗法。
■Fournier坏疽是一种泌尿外科急症，死亡率很高。感染的侵袭性需要早期识别和立即手术干预。应更常规地使用负压敷料和偶尔使用高压氧作为辅助手段，特别是如果对常规治疗或严重感染有延迟反应。
