PDF(Pubmed)
Abstract：
Twenty nail dystrophy refers to the condition of trachyonychia affecting all the twenty nails. The term trachyonychia is used to describe thin brittle nails with excessive longitudinal ridging. Treatment of twenty nail dystrophy is difficult due to poor bioavailability of drugs in nails. Tofacitinib is novel JAK-STAT inhibitor that has been used successfully for the treatment of nail dystrophy with alopecia areata suggests the possibility of the drug being used for twenty nail dystrophy.
摘要：
20个指甲营养不良是指影响所有20个指甲的全甲。术语“骨甲”用于描述具有过度纵向起皱的薄脆指甲。由于指甲中药物的生物利用度差,治疗20个指甲营养不良是困难的。Tofacitinib是新型JAK-STAT抑制剂，已成功用于治疗斑秃的指甲营养不良，这表明该药物有可能用于治疗20种指甲营养不良。
