METHODS: Thirty-nine subjects with relapsing MS completed a 6-month ketogenic diet intervention. NfL levels were assayed at both baseline (pre-diet) and 6-months on-diet. In addition, ketogenic diet study participants were compared to a cohort (n = 31) of historical, untreated MS controls.
RESULTS: Baseline (pre-diet) mean NfL was 5.45 pg/ml (95% CI 4.59 - 6.31). After 6 months on ketogenic diet, mean NfL was not significantly changed (5.49 pg/ml; 95% CI 4.82 - 6.19). Compared to untreated MS controls (mean 15.17 pg/ml), NfL levels for the ketogenic diet cohort were relatively low. MS subjects with higher levels of ketosis (as measured by serum beta-hydroxybutyrate) exhibited greater reductions in NfL between baseline and 6-months on ketogenic diet.
CONCLUSIONS: Ketogenic diets do not worsen biomarkers of neurodegeneration in relapsing MS patients, with stable, low levels of NfL observed throughout the diet intervention. Subjects with greater biomarkers of ketosis experienced a higher degree of improvement in serum NfL.
BACKGROUND: NCT03718247 - \"Utilization of the Ketogenic Diet in Patients with Relapsing-Remitting MS\" https://clinicaltrials.gov/ct2/show/NCT03718247.
方法:39例复发性MS患者完成了为期6个月的生酮饮食干预。在基线(饮食前)和6个月饮食时测定NfL水平。此外,生酮饮食研究参与者与一个历史队列(n=31)进行了比较,未处理的MS对照。
结果:基线(饮食前)平均NfL为5.45pg/ml(95%CI4.59-6.31)。生酮饮食6个月后,平均NfL无显著变化(5.49pg/ml;95%CI4.82-6.19)。与未经处理的MS对照(平均15.17pg/ml)相比,生酮饮食队列的NfL水平相对较低。具有较高水平的酮症(如通过血清β-羟基丁酸酯测量的)的MS受试者在基线和生酮饮食的6个月之间表现出更大的NfL降低。
结论:生酮饮食不会使复发性MS患者神经变性的生物标志物恶化,稳定,在整个饮食干预中观察到低水平的NfL。具有更高的酮症生物标志物的受试者在血清NfL中经历了更高程度的改善。
背景:NCT03718247-\"复发MS患者使用生酮饮食\"https://clinicaltrials.gov/ct2/show/NCT03718247。