UNASSIGNED: Colorectal HD specimens were measured at the time of surgery and at the time of cut-up, either fresh or after formalin fixation and statistically analyzed.
UNASSIGNED: Sixteen colorectal specimens were included. Following formalin fixation the specimen length decreased by 22.7% (P < .001). Without formalin fixation the specimens shrank by an average of 24.9% (P = .05). There was no significant difference in the extent of tissue shrinkage with or without formalin fixation (P = .76).
UNASSIGNED: This study showed that there is significant tissue shrinkage in HD specimens. The 2 different cohorts revealed that tissue shrinkage is mostly caused by tissue retraction/alteration after organ removal but also to a lesser extent by fixation with formalin. Surgeons and (neuro-)pathologists should be aware of the sizeable shrinking artifact to avoid unnecessary confusion.
■在手术时和切割时测量结直肠HD标本,新鲜或福尔马林固定后进行统计分析。
■包括16个结肠直肠标本。福尔马林固定后,标本长度减少了22.7%(P<.001)。没有福尔马林固定,标本平均收缩24.9%(P=0.05)。有或没有福尔马林固定的组织收缩程度没有显着差异(P=0.76)。
■这项研究表明,HD标本中存在明显的组织收缩。2个不同的队列显示,组织收缩主要是由器官切除后的组织收缩/改变引起的,但在较小程度上也是由福尔马林固定引起的。外科医生和(神经)病理学家应该意识到相当大的收缩伪影,以避免不必要的混乱。