PDF(Pubmed)
Abstract：
UNASSIGNED: Hirschsprung disease (HD) is an aganglionosis of variable length starting at the rectosigmoid colon with surgery as sole therapeutic option. The length of the resected bowel segment is a crucial information for the treating surgeons and influences the prognosis of the patient. It is often artificially altered due to post operative tissue shrinkage. The objective of this study is to quantify the extent tissue shrinkage of HD specimens.
UNASSIGNED: Colorectal HD specimens were measured at the time of surgery and at the time of cut-up, either fresh or after formalin fixation and statistically analyzed.
UNASSIGNED: Sixteen colorectal specimens were included. Following formalin fixation the specimen length decreased by 22.7% (P < .001). Without formalin fixation the specimens shrank by an average of 24.9% (P = .05). There was no significant difference in the extent of tissue shrinkage with or without formalin fixation (P = .76).
UNASSIGNED: This study showed that there is significant tissue shrinkage in HD specimens. The 2 different cohorts revealed that tissue shrinkage is mostly caused by tissue retraction/alteration after organ removal but also to a lesser extent by fixation with formalin. Surgeons and (neuro-)pathologists should be aware of the sizeable shrinking artifact to avoid unnecessary confusion.
UNASSIGNED: Colorectal HD specimens were measured at the time of surgery and at the time of cut-up, either fresh or after formalin fixation and statistically analyzed.
UNASSIGNED: Sixteen colorectal specimens were included. Following formalin fixation the specimen length decreased by 22.7% (P < .001). Without formalin fixation the specimens shrank by an average of 24.9% (P = .05). There was no significant difference in the extent of tissue shrinkage with or without formalin fixation (P = .76).
UNASSIGNED: This study showed that there is significant tissue shrinkage in HD specimens. The 2 different cohorts revealed that tissue shrinkage is mostly caused by tissue retraction/alteration after organ removal but also to a lesser extent by fixation with formalin. Surgeons and (neuro-)pathologists should be aware of the sizeable shrinking artifact to avoid unnecessary confusion.
摘要：
■Hirschsprung病（HD）是一种长度可变的神经节病，始于直肠乙状结肠，手术是唯一的治疗选择。切除的肠段的长度是治疗外科医生的重要信息，并影响患者的预后。通常由于术后组织收缩而人为改变。这项研究的目的是量化HD标本的组织收缩程度。
■在手术时和切割时测量结直肠HD标本，新鲜或福尔马林固定后进行统计分析。
■包括16个结肠直肠标本。福尔马林固定后，标本长度减少了22.7%(P<.001)。没有福尔马林固定，标本平均收缩24.9%（P=0.05）。有或没有福尔马林固定的组织收缩程度没有显着差异（P=0.76）。
■这项研究表明，HD标本中存在明显的组织收缩。2个不同的队列显示，组织收缩主要是由器官切除后的组织收缩/改变引起的，但在较小程度上也是由福尔马林固定引起的。外科医生和（神经）病理学家应该意识到相当大的收缩伪影，以避免不必要的混乱。
■在手术时和切割时测量结直肠HD标本，新鲜或福尔马林固定后进行统计分析。
■包括16个结肠直肠标本。福尔马林固定后，标本长度减少了22.7%(P<.001)。没有福尔马林固定，标本平均收缩24.9%（P=0.05）。有或没有福尔马林固定的组织收缩程度没有显着差异（P=0.76）。
■这项研究表明，HD标本中存在明显的组织收缩。2个不同的队列显示，组织收缩主要是由器官切除后的组织收缩/改变引起的，但在较小程度上也是由福尔马林固定引起的。外科医生和（神经）病理学家应该意识到相当大的收缩伪影，以避免不必要的混乱。
