PDF(Pubmed)
Abstract：
Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects elderly individuals. The presentation of BP is heterogeneous, typically manifesting as microscopic subepidermal separation with a mixed inflammatory infiltrate. The mechanism of pemphigoid development is unclear. B cells play a major role in pathogenic autoantibody production, and T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes are also implicated in the pathogenesis of BP. Here, we review the roles of and crosstalk between innate and adaptive immune cells in BP.
摘要：
大疱性类天疱疮（BP）是一种自身免疫性水疱疾病，主要影响老年人。BP的表示是异构的，通常表现为混合炎症浸润的微观表皮下分离。类天疱疮的发展机制尚不清楚。B细胞在致病性自身抗体产生中起主要作用，T细胞,II型炎症细胞因子，嗜酸性粒细胞,肥大细胞,中性粒细胞，和角质形成细胞也与BP的发病机理有关。这里,我们综述了先天免疫细胞和适应性免疫细胞在BP中的作用和相互作用。
