Abstract：
Sinonasal mucosal melanoma (SNMM) is a rare malignant neoplasm. The regional failure pattern and effectiveness of elective neck irradiation (ENI) were not well defined. Here, we would assess the value of ENI for clinical node negative (cN0) SNMM patients.
A total of 107 SNMM patients treated at our institution over a period of 30 years was retrospectively analyzed.
Five patients had lymph node metastases at diagnosis. Among the 102 cN0 patients analyzed, 37 patients had received ENI, and 65 patients had not. ENI significantly reduced the regional recurrence rate from 23.1% (15/65) to 2.7% (1/37). Ipsilateral levels Ib and II were the most common locations of regional relapse. Multivariate analysis also showed that ENI was the only independent favorable predictor for the achievement of regional control (HR: 9.120; 95% CI: 1.204-69.109; P = 0.032).
This is the largest cohort of SNMM patients from a single institution analyzed for the assessment of the value of ENI on regional control and survival. ENI significantly reduced the regional relapse rate in our study. Ipsilateral levels Ib and II might be considerable when deliver elective neck irradiation, more evidence is needed in the future.
A total of 107 SNMM patients treated at our institution over a period of 30 years was retrospectively analyzed.
Five patients had lymph node metastases at diagnosis. Among the 102 cN0 patients analyzed, 37 patients had received ENI, and 65 patients had not. ENI significantly reduced the regional recurrence rate from 23.1% (15/65) to 2.7% (1/37). Ipsilateral levels Ib and II were the most common locations of regional relapse. Multivariate analysis also showed that ENI was the only independent favorable predictor for the achievement of regional control (HR: 9.120; 95% CI: 1.204-69.109; P = 0.032).
This is the largest cohort of SNMM patients from a single institution analyzed for the assessment of the value of ENI on regional control and survival. ENI significantly reduced the regional relapse rate in our study. Ipsilateral levels Ib and II might be considerable when deliver elective neck irradiation, more evidence is needed in the future.
摘要：
目的：鼻窦粘膜黑色素瘤（SNMM）是一种罕见的恶性肿瘤。选择性颈部照射（ENI）的区域失效模式和有效性尚未明确。这里,我们将评估ENI对临床淋巴结阴性(cN0)SNMM患者的价值。
方法：回顾性分析了在我们机构治疗30年的107例SNMM患者。
结果：5例患者在诊断时出现淋巴结转移。在分析的102名cN0患者中，37名患者接受了ENI，65名患者没有。ENI将区域复发率从23.1％（15/65）显着降低到2.7％（1/37）。同侧水平Ib和II是区域复发的最常见位置。多因素分析还显示，ENI是实现区域控制的唯一独立有利预测因子（HR：9.120；95％CI：1.204-69.109；P=0.032）。
结论：这是为评估ENI对区域控制和生存的价值而分析的来自单一机构的最大的SNMM患者队列。在我们的研究中，ENI显著降低了区域复发率。进行选择性颈部照射时，同侧水平Ib和II可能相当大，未来需要更多的证据。
方法：回顾性分析了在我们机构治疗30年的107例SNMM患者。
结果：5例患者在诊断时出现淋巴结转移。在分析的102名cN0患者中，37名患者接受了ENI，65名患者没有。ENI将区域复发率从23.1％（15/65）显着降低到2.7％（1/37）。同侧水平Ib和II是区域复发的最常见位置。多因素分析还显示，ENI是实现区域控制的唯一独立有利预测因子（HR：9.120；95％CI：1.204-69.109；P=0.032）。
结论：这是为评估ENI对区域控制和生存的价值而分析的来自单一机构的最大的SNMM患者队列。在我们的研究中，ENI显著降低了区域复发率。进行选择性颈部照射时，同侧水平Ib和II可能相当大，未来需要更多的证据。
