Abstract：
Peliosis hepatis (PH) is a rare benign condition, characterized by hepatic sinusoidal dilatation and blood-filled cystic cavities, often found incidentally, with still challenging diagnosis by imaging due to polymorphic appearance.
Based on a retrospective analysis of our series (12 patients) and systematic literature review (1990-2022), to organize data about PH and identify features to improve characterization.
Retrospective case series and systematic review.
Twelve patients (mean age 48 years, 55% female) with pathology-proven PH and 49 patients (mean age 52 years, 67% female) identified in 33 studies from the literature (1990-2022).
1,5-T; T1-weighted (T1W), T2-weighted (T2W), diffusion-weighted (DW), contrast-enhanced (CE) T1W imaging.
We compared our series and literature data in terms of demographic (gender/age/ethnicity), clinical characteristics (symptoms/physical examination/liver test), associated conditions (malignancies/infectious/hematologic/genetic or chronic disorders/drugs or toxic exposure) percentage. On magnetic resonance imaging lesion numbers/shape/mean maximum diameter/location/mass effect/signal intensity were compared. PH pathological type/proposed imaging diagnosis/patient follow-up were also considered.
Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports/Series quality assessment. Intraclass correlation and Cohen\'s kappa coefficients for levels of inter/intrareader agreement in our experience.
Patients were mainly asymptomatic (92% vs. 70% in our study and literature) with associated conditions (83% vs. 80%). Lesions showed homogeneous T1W-hypointensity (58% vs. 65%) and T2W-hyperintensity (58% vs. 66%). Heterogeneous nonspecific (25% vs. 51%), centrifugal (34% vs. 8%), or rim-like centripetal (25% vs. 23%) patterns of enhancement were most frequent, with hypointensity on the hepatobiliary phase (HBP), without restricted diffusivity. Good inter- and intrareader agreement was observed in our experience. Concerning JBI Checklist, 19 out of 31 case reports met at least 7 out of 8 criteria, whereas 2 case series fulfilled 5 and 6 out of 10 items respectively.
A homogeneous, not well-demarcated T1W-hypointense and T2W-hyperintense mass, with heterogeneous nonspecific or rim-like centripetal or centrifugal pattern of enhancement, and hypointensity on HBP, may be helpful for PH diagnosis. Among associated conditions, malignancies and drug exposures were the most frequent.
4 TECHNICAL EFFICACY: Stage 2.
Based on a retrospective analysis of our series (12 patients) and systematic literature review (1990-2022), to organize data about PH and identify features to improve characterization.
Retrospective case series and systematic review.
Twelve patients (mean age 48 years, 55% female) with pathology-proven PH and 49 patients (mean age 52 years, 67% female) identified in 33 studies from the literature (1990-2022).
1,5-T; T1-weighted (T1W), T2-weighted (T2W), diffusion-weighted (DW), contrast-enhanced (CE) T1W imaging.
We compared our series and literature data in terms of demographic (gender/age/ethnicity), clinical characteristics (symptoms/physical examination/liver test), associated conditions (malignancies/infectious/hematologic/genetic or chronic disorders/drugs or toxic exposure) percentage. On magnetic resonance imaging lesion numbers/shape/mean maximum diameter/location/mass effect/signal intensity were compared. PH pathological type/proposed imaging diagnosis/patient follow-up were also considered.
Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports/Series quality assessment. Intraclass correlation and Cohen\'s kappa coefficients for levels of inter/intrareader agreement in our experience.
Patients were mainly asymptomatic (92% vs. 70% in our study and literature) with associated conditions (83% vs. 80%). Lesions showed homogeneous T1W-hypointensity (58% vs. 65%) and T2W-hyperintensity (58% vs. 66%). Heterogeneous nonspecific (25% vs. 51%), centrifugal (34% vs. 8%), or rim-like centripetal (25% vs. 23%) patterns of enhancement were most frequent, with hypointensity on the hepatobiliary phase (HBP), without restricted diffusivity. Good inter- and intrareader agreement was observed in our experience. Concerning JBI Checklist, 19 out of 31 case reports met at least 7 out of 8 criteria, whereas 2 case series fulfilled 5 and 6 out of 10 items respectively.
A homogeneous, not well-demarcated T1W-hypointense and T2W-hyperintense mass, with heterogeneous nonspecific or rim-like centripetal or centrifugal pattern of enhancement, and hypointensity on HBP, may be helpful for PH diagnosis. Among associated conditions, malignancies and drug exposures were the most frequent.
4 TECHNICAL EFFICACY: Stage 2.
摘要：
背景：肝硬化(PH)是一种罕见的良性疾病，以肝窦扩张和充满血液的囊腔为特征，经常偶然发现，由于多态外观，通过成像诊断仍然具有挑战性。
目的：基于我们系列（12例）的回顾性分析和系统文献综述（1990-2022），组织有关PH的数据并识别特征以改善表征。
方法：回顾性病例系列和系统评价。
方法：12名患者（平均年龄48岁，55％女性）经病理证实的PH和49例患者（平均年龄52岁，67%的女性)在33项研究中从文献(1990-2022年)中确定。
■1,5-T；T1加权(T1W)，T2加权(T2W),扩散加权(DW)，对比增强（CE）T1W成像。
结果：我们在人口统计学（性别/年龄/种族）方面比较了我们的系列和文献数据，临床特征（症状/体格检查/肝脏检查），相关疾病（恶性肿瘤/感染性/血液学/遗传性或慢性疾病/药物或毒性暴露）百分比。在磁共振成像上，比较了病变数量/形状/平均最大直径/位置/质量效应/信号强度。还考虑了PH病理类型/建议的影像学诊断/患者随访。
方法：JoannaBriggsInstitute(JBI)病例报告/系列质量评估关键评估清单。在我们的经验中，类内相关性和科恩的卡帕系数对交易者间/内部协议水平的影响。
结果：患者主要无症状(92%vs.在我们的研究和文献中为70％）与相关条件（83％与80%)。病变表现为均匀的T1W-低张力(58%vs.65%）和T2W高强度（58%vs.66%）。异质性非特异性(25%与51%），离心(34%vs.8%),或边缘状向心(25%与23%)的增强模式最常见，肝胆期低张力（HBP），没有限制的扩散。在我们的经验中，我们观察到了良好的内部和内部协议。关于JBI清单，31例病例报告中有19例符合8项标准中的至少7项，而2个案例系列分别满足了10个项目中的5个和6个。
结论：同质，没有很好地划分T1W-低信号和T2W-高强度质量，具有异质的非特异性或边缘状向心或离心增强模式，和HBP上的低强度，可能有助于PH诊断。在相关条件中，恶性肿瘤和药物暴露是最常见的.
方法：4技术效果：阶段2。
目的：基于我们系列（12例）的回顾性分析和系统文献综述（1990-2022），组织有关PH的数据并识别特征以改善表征。
方法：回顾性病例系列和系统评价。
方法：12名患者（平均年龄48岁，55％女性）经病理证实的PH和49例患者（平均年龄52岁，67%的女性)在33项研究中从文献(1990-2022年)中确定。
■1,5-T；T1加权(T1W)，T2加权(T2W),扩散加权(DW)，对比增强（CE）T1W成像。
结果：我们在人口统计学（性别/年龄/种族）方面比较了我们的系列和文献数据，临床特征（症状/体格检查/肝脏检查），相关疾病（恶性肿瘤/感染性/血液学/遗传性或慢性疾病/药物或毒性暴露）百分比。在磁共振成像上，比较了病变数量/形状/平均最大直径/位置/质量效应/信号强度。还考虑了PH病理类型/建议的影像学诊断/患者随访。
方法：JoannaBriggsInstitute(JBI)病例报告/系列质量评估关键评估清单。在我们的经验中，类内相关性和科恩的卡帕系数对交易者间/内部协议水平的影响。
结果：患者主要无症状(92%vs.在我们的研究和文献中为70％）与相关条件（83％与80%)。病变表现为均匀的T1W-低张力(58%vs.65%）和T2W高强度（58%vs.66%）。异质性非特异性(25%与51%），离心(34%vs.8%),或边缘状向心(25%与23%)的增强模式最常见，肝胆期低张力（HBP），没有限制的扩散。在我们的经验中，我们观察到了良好的内部和内部协议。关于JBI清单，31例病例报告中有19例符合8项标准中的至少7项，而2个案例系列分别满足了10个项目中的5个和6个。
结论：同质，没有很好地划分T1W-低信号和T2W-高强度质量，具有异质的非特异性或边缘状向心或离心增强模式，和HBP上的低强度，可能有助于PH诊断。在相关条件中，恶性肿瘤和药物暴露是最常见的.
方法：4技术效果：阶段2。
