PDF(Pubmed)
Abstract：
Laser Doppler imaging (LDI) technology has been validated to assess thermal burn depth by predicting wound healing potential. However, there is no clear evidence for its use in chemical burns. We present a case of an 8% total burn surface area (TBSA) nitric acid burn following an industrial accident, in an otherwise healthy 36-year-old man. LDI assessment was suggestive of poor healing potential of >21 days, warranting surgical management. However, conservative management was opted for based on clinical assessment as the wound eschar appeared thin and more consistent with epithelial staining. Patient follow-up confirmed a total burn healing time of two months, suggesting that the LDI assessment was accurate. A comprehensive literature review was performed using the MEDLINE (PubMed) database to identify animal or clinical studies evaluating the efficacy of LDI in chemical burns. A qualitative synthesis of our findings is presented. We identified two experimental studies in porcine models with sulfur mustard burns, each confirming the accuracy of LDI assessment when compared to the histopathology findings. Limited experimental animal studies on the use of LDI suggest similar validity in chemical burns, and this correlates with the clinical outcome in this case. However, this alone is insufficient to prove its validity and define its role in the assessment of chemical burns. Clinical trials are required to further assess and define the parameters of LDI use and efficacy in this context.
摘要：
激光多普勒成像（LDI）技术已被验证为通过预测伤口愈合潜力来评估热烧伤深度。然而,没有明确的证据证明其用于化学烧伤。我们介绍了工业事故后8％的总烧伤表面积（TBSA）硝酸烧伤的情况，一个健康的36岁男子.LDI评估提示>21天的不良愈合潜力，保证手术管理。然而,我们根据临床评估选择保守治疗,因为伤口焦痂较薄,且与上皮染色更为一致.患者随访证实烧伤总愈合时间为2个月，表明LDI评估是准确的.使用MEDLINE（PubMed）数据库进行了全面的文献综述，以确定评估LDI在化学烧伤中功效的动物或临床研究。对我们的研究结果进行了定性综合。我们在硫芥末烧伤的猪模型中确定了两项实验研究，与组织病理学结果进行比较时,均证实了LDI评估的准确性.关于使用LDI的有限的实验动物研究表明，在化学烧伤中具有相似的有效性，在这种情况下，这与临床结果相关。然而,仅凭这一点不足以证明其有效性并确定其在化学烧伤评估中的作用。在这种情况下，需要进行临床试验以进一步评估和定义LDI使用和疗效的参数。
