Abstract：
Several developments and research methods are ongoing in drug technology and chemistry research to elicit effectiveness regarding the therapeutic activity of drugs along with photoprotection for their molecular integrity. The detrimental effect of UV light induces damaged cells and DNA, which leads to skin cancer and other phototoxic effects. The application of sunscreen shields to the skin is important, along with recommended UV filters. Avobenzone is widely used as a UVA filter for skin photoprotection in sunscreen formulations. However, keto-enol tautomerism propagates photodegradation into it, which further channelizes the phototoxic and photoirradiation effects, further limiting its use. Several approaches have been used to counter these issues, including encapsulation, antioxidants, photostabilizers, and quenchers. To seek the gold standard approach for photoprotection in photosensitive drugs, combinations of strategies have been implemented to identify effective and safe sunscreen agents. The stringent regulatory guidelines for sunscreen formulations, along with the availability of limited FDA-approved UV filters, have led many researchers to develop perfect photostabilization strategies for available photostable UV filters, such as avobenzone. From this perspective, the objective of the current review is to summarize the recent literature on drug delivery strategies implemented for the photostabilization of avobenzone that could be useful to frame industrially oriented potential strategies on a large scale to circumvent all possible photounstable issues of avobenzone.
摘要：
在药物技术和化学研究中正在进行一些开发和研究方法，以引起药物治疗活性的有效性以及其分子完整性的光保护。紫外线的有害作用会导致细胞和DNA受损，导致皮肤癌和其他光毒性作用。防晒霜在皮肤上的应用很重要，以及推荐的紫外线过滤器。阿伏苯宗广泛用作UVA滤光剂,用于防晒制剂中的皮肤光保护。然而,酮-烯醇互变异构将光降解传播到其中，这进一步引导了光毒性和光辐射效应，进一步限制其使用。已经使用了几种方法来解决这些问题，包括封装，抗氧化剂,光稳定剂,和淬火剂。寻求光敏药物光保护的金标准方法，已经实施了多种策略组合来确定有效和安全的防晒剂。防晒配方的严格监管准则，随着有限的FDA批准的紫外线过滤器的可用性，已经导致许多研究人员为可用的光稳定紫外线过滤器开发完美的光稳定策略，如avobenzone。从这个角度来看,本综述的目的是总结最近关于阿伏苯宗光稳定给药策略的文献，这些文献可能有助于大规模构建面向工业的潜在策略，以规避阿伏苯宗的所有可能的光不稳定问题。
