PDF(Pubmed)
Abstract：
The FOXP3 transcription factor is a marker of regulatory T cells (Tregs), and is essential in the process of their activation and proper expression by promoting immune homeostasis. To assess the influence of the environment on the development of asthma, we hypothesized that in our cohort, exposure to environmental factors is associated with asthma risk in children, and that FOXP3 levels vary with their incidence and are negatively correlated with developing asthma. This prospective study conducted in Poland uses a cohort of 85 children (42 with and 43 without asthma diagnosis) aged 9 to 12 years recruited for the Polish Mother and Child Cohort Study. We collected questionnaires and organized visits to assess patients\' clinical condition (skin prick tests, lung function assessments). Blood samples were taken to determine immune parameters. Breastfed children had lower risk of asthma. Asthma risk was higher in children who live in the city, with antibiotic course before the age of 2 and antibiotic therapy more than twice a year. Environmental factors were associated with childhood asthma. Breastfeeding, the coexistence of other allergic diseases, and the frequency of housekeeping affect FOXP3 levels, which are negatively correlated with the risk of asthma.
摘要：
FOXP3转录因子是调节性T细胞（Tregs）的标记，并且通过促进免疫稳态在其激活和适当表达的过程中是必不可少的。评估环境对哮喘发展的影响，我们假设在我们的队列中，暴露于环境因素与儿童哮喘风险相关，FOXP3水平随发病率的变化而变化，并且与哮喘的发展呈负相关。这项在波兰进行的前瞻性研究使用了85名9至12岁的儿童（42名患有哮喘，43名没有哮喘诊断），招募了波兰母婴队列研究。我们收集问卷并组织访问以评估患者的临床状况(皮肤点刺试验，肺功能评估)。采集血液样品以确定免疫参数。母乳喂养的儿童患哮喘的风险较低。居住在城市的儿童患哮喘的风险更高，2岁前的抗生素疗程和抗生素治疗每年两次以上。环境因素与儿童哮喘相关。母乳喂养,其他过敏性疾病的共存，内务管理的频率会影响FOXP3水平，与哮喘的风险呈负相关。
