Abstract：
The enteric nervous system (ENS), the inherent nervous system of the gastrointestinal (GI) tract is a vast nervous system that controls key GI functions, including motility. It functions at a critical interface between the gut luminal contents, including the diverse population of microorganisms deemed the microbiota, as well as the autonomic and central nervous systems. Critical development of this axis of interaction, a key determinant of human health and disease, appears to occur most significantly during early life and childhood, from the pre-natal through to the post-natal period. These factors that enable the ENS to function as a master regulator also make it vulnerable to damage and, in turn, a number of GI motility disorders. Increasing attention is now being paid to the potential of disruption of the microbiota and pathogenic microorganisms in the potential aetiopathogeneis of GI motility disorders in children. This article explores the evidence regarding the relationship between the development and integrity of the ENS and the potential for such factors, notably dysbiosis and pathogenic bacteria, viruses and parasites, to impact upon them in early life.
摘要：
肠神经系统（ENS），胃肠道（GI）的固有神经系统是一个巨大的神经系统，控制关键的胃肠道功能，包括运动性。它在肠道腔内容物之间的关键界面起作用，包括被认为是微生物群的不同微生物群体，以及自主神经和中枢神经系统。这个互动轴的关键发展，人类健康和疾病的关键决定因素，似乎最明显地发生在早期生活和儿童时期，从产前到产后。这些使ENS能够充当主调节器的因素也使其容易受到损害，反过来,一些胃肠道运动障碍。现在，越来越多的人关注儿童胃肠动力障碍的潜在病因中微生物群和病原微生物的破坏。本文探讨了有关ENS的发展和完整性与此类因素的潜力之间关系的证据，特别是生态失调和致病菌，病毒和寄生虫,影响他们的早期生活。
