Abstract：
Bacterial infection can occur in patients hospitalized with SARS-CoV-2 in various conditions, resulting in poorer outcomes, such as a higher death rate. This current systematic review was conducted in order to assess the efficiency of multiplex PCR in detecting bacterial infections in hospitalized COVID-19 patients, as well as to analyze the most common bacterial pathogens and other factors that interfere with this diagnosis. The research was conducted using four electronic databases (PubMed, Taylor&Francis, Web of Science, and Wiley Online Library). Out of 290 studies, nine were included in the systematic review. The results supported the use of multiplex PCR in detecting bacteria, considering its high sensitivity and specificity rates. The most common bacterial pathogens found were Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae, and Haemophilus influenzae. The median age at admission was 61.5 years, and the majority of patients were men (70.3%), out of a total of 1553 patients. The proportion of ICU admission was very high, with a pooled proportion of 52.6% over the analyzed studies, and an average duration of hospitalization of 13 days. The mortality rate was proportionally high, as was the rate of ICU admission, with a pooled mortality of 24.9%. It was discovered that 65.2% of all patients used antibiotics before admission, with or without medical prescription. Antibiotic treatment should be considered consciously, considering the high risks of developing antibiotic resistance.
摘要：
在各种情况下，SARS-CoV-2住院患者可发生细菌感染，导致较差的结果，比如更高的死亡率。这项系统评价是为了评估多重PCR检测住院COVID-19患者细菌感染的效率。以及分析最常见的细菌病原体和其他干扰这种诊断的因素。这项研究是使用四个电子数据库(PubMed，泰勒和弗朗西斯，WebofScience,和Wiley在线图书馆）。在290项研究中，9项纳入了系统审查。结果支持使用多重PCR检测细菌，考虑到其高灵敏度和特异性。最常见的细菌病原体是肺炎克雷伯菌，金黄色葡萄球菌,铜绿假单胞菌,肺炎链球菌,和流感嗜血杆菌.入院时的平均年龄为61.5岁，大多数患者是男性（70.3%），在总共1553名患者中。入住ICU的比例很高，在分析的研究中，合并比例为52.6%，平均住院时间为13天。死亡率成比例地高，ICU入院率也是如此，合并死亡率为24.9%。发现65.2%的患者在入院前使用抗生素,有或没有医疗处方。应该有意识地考虑抗生素治疗，考虑到抗生素耐药性的高风险。
