关键词: Adjuvant therapy Postoperative therapy Safety margin Sentinel lymph node Tumor bed

Mesh : Humans Carcinoma, Merkel Cell / radiotherapy Sentinel Lymph Node Biopsy Skin Neoplasms / pathology Lymphatic Metastasis / pathology Lymph Node Excision Lymph Nodes / pathology

来  源:   DOI:10.1007/s00066-023-02068-8   PDF(Pubmed)

Abstract:
Merkel cell carcinoma (MCC) is a radiosensitive tumor and the role of radiotherapy in the management of this disease was newly defined in the recently published update of the S2k guideline on Merkel cell carcinoma of the Association of Scientific Medical Societies in Germany (AWMF). While adjuvant radiotherapy of the tumor bed is broadly recommended, irradiation of the regional nodal region can be performed in patients with negative sentinel lymph nodes and high-risk factors. In patients with positive sentinel lymph nodes, it is an alternative to completion lymphadenectomy. The standard dose for adjuvant radiotherapy remains 50 Gy.
摘要:
默克尔细胞癌(MCC)是一种对放射敏感的肿瘤,在最近发布的德国科学医学会(AWMF)关于默克尔细胞癌的S2k指南的更新中,对放射疗法在这种疾病的治疗中的作用进行了新定义。虽然肿瘤床的辅助放疗被广泛推荐,前哨淋巴结阴性和高危因素的患者可以进行区域淋巴结区域的照射。在前哨淋巴结阳性的患者中,它是完成淋巴结清扫术的替代方法。辅助放疗的标准剂量仍为50Gy。
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