PDF(Pubmed)
Abstract：
BACKGROUND: Dermatosis is a general term for diseases of the skin and skin appendages including scleroderma, psoriasis, bullous disease, atopic dermatitis, basal cell carcinoma, squamous cell carcinoma, and melanoma. These diseases affect millions of individuals globally and are a serious public health concern. However, the pathogenesis of skin diseases is not fully understood, and treatments are not optimal. Yes-associated protein (YAP) is a transcriptional coactivator that plays a role in the regulation of gene transcription and signal transduction.
OBJECTIVE: To study the role of Yes-associated protein in skin diseases.
METHODS: The present review summarizes recent advances in our understanding of the role of YAP in skin diseases, current treatments that target YAP, and potential avenues for novel therapies.
RESULTS: Abnormal YAP expression has been implicated in occurrence and development of dermatosis. YAP regulates the cell homeostasis, proliferation, differentiation, apoptosis, angiopoiesis, and epithelial-to-mesenchymal transition, among other processes. As well as, it serves as a potential target in many biological processes for treating dermatosis.
CONCLUSIONS: The effects of YAP on the skin are complex and require multidimensional investigational approaches. YAP functions as an oncoprotein that can promote the occurrence and development of cancer, but there is currently limited information on the therapeutic potential of YAP inhibition for cancer treatment. Additional studies are also needed to clarify the role of YAP in the development and maturation of dermal fibroblasts; skin barrier function, homeostasis, aging, and melanin production; and dermatosis.
OBJECTIVE: To study the role of Yes-associated protein in skin diseases.
METHODS: The present review summarizes recent advances in our understanding of the role of YAP in skin diseases, current treatments that target YAP, and potential avenues for novel therapies.
RESULTS: Abnormal YAP expression has been implicated in occurrence and development of dermatosis. YAP regulates the cell homeostasis, proliferation, differentiation, apoptosis, angiopoiesis, and epithelial-to-mesenchymal transition, among other processes. As well as, it serves as a potential target in many biological processes for treating dermatosis.
CONCLUSIONS: The effects of YAP on the skin are complex and require multidimensional investigational approaches. YAP functions as an oncoprotein that can promote the occurrence and development of cancer, but there is currently limited information on the therapeutic potential of YAP inhibition for cancer treatment. Additional studies are also needed to clarify the role of YAP in the development and maturation of dermal fibroblasts; skin barrier function, homeostasis, aging, and melanin production; and dermatosis.
摘要：
背景：皮肤病是皮肤和皮肤附件疾病的总称，包括硬皮病，牛皮癣,大疱性疾病,特应性皮炎,基底细胞癌,鳞状细胞癌,还有黑色素瘤.这些疾病影响全球数百万人，是一个严重的公共卫生问题。然而,皮肤病的发病机制尚未完全了解，和治疗不是最佳的。Yes相关蛋白（YAP）是一种转录共激活因子，在调节基因转录和信号转导中起作用。
目的：研究Yes相关蛋白在皮肤病中的作用。
方法：本综述总结了我们对YAP在皮肤病中的作用的理解的最新进展。目前针对YAP的治疗方法，以及新疗法的潜在途径。
结果：YAP表达异常与皮肤病的发生和发展有关。YAP调节细胞稳态，扩散,分化,凋亡，血管生成,和上皮-间质转化，在其他过程中。还有,在许多治疗皮肤病的生物学过程中，它是一个潜在的靶点。
结论：YAP对皮肤的影响是复杂的，需要多维度的研究方法。YAP作为一种癌蛋白，可以促进癌症的发生和发展，但目前关于YAP抑制用于癌症治疗的治疗潜力的信息有限.还需要进一步的研究来阐明YAP在真皮成纤维细胞发育和成熟中的作用；皮肤屏障功能，稳态，老化，和黑色素产生；和皮肤病。
目的：研究Yes相关蛋白在皮肤病中的作用。
方法：本综述总结了我们对YAP在皮肤病中的作用的理解的最新进展。目前针对YAP的治疗方法，以及新疗法的潜在途径。
结果：YAP表达异常与皮肤病的发生和发展有关。YAP调节细胞稳态，扩散,分化,凋亡，血管生成,和上皮-间质转化，在其他过程中。还有,在许多治疗皮肤病的生物学过程中，它是一个潜在的靶点。
结论：YAP对皮肤的影响是复杂的，需要多维度的研究方法。YAP作为一种癌蛋白，可以促进癌症的发生和发展，但目前关于YAP抑制用于癌症治疗的治疗潜力的信息有限.还需要进一步的研究来阐明YAP在真皮成纤维细胞发育和成熟中的作用；皮肤屏障功能，稳态，老化，和黑色素产生；和皮肤病。
