PDF(Pubmed)
Abstract：
Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected under invasive or terminal procedures. Currently, animal acquisitions are performed with varying protocols and analyses that hamper result comparison and integration. Here we introduce StandardRat, a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers. To develop this protocol with optimized acquisition and processing parameters, we initially aggregated 65 functional imaging datasets acquired from rats across 46 centers. We developed a reproducible pipeline for analyzing rat data acquired with diverse protocols and determined experimental and processing parameters associated with the robust detection of functional connectivity across centers. We show that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions. The protocol and processing pipeline described here is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.
摘要：
动物模型中的无任务功能连通性提供了一个实验框架来检查受控条件下的连通性现象，并允许与在侵入性或最终程序下收集的数据模态进行比较。目前,动物采集采用不同的方案和分析进行，这妨碍了结果比较和整合。这里我们介绍StandardRat,在20个中心测试了一致的大鼠功能磁共振成像采集方案.为了开发具有优化的采集和处理参数的协议，我们最初汇总了来自46个中心的大鼠的65个功能成像数据集.我们开发了一个可重复的管道，用于分析通过不同协议获取的大鼠数据，并确定了与跨中心功能连接的强大检测相关的实验和处理参数。我们表明，相对于以前的采集，标准化协议增强了生物学上合理的功能连接模式。这里描述的协议和处理管道与神经成像界公开共享，以促进互操作性和合作，以应对神经科学中最重要的挑战。
