PDF(Pubmed)
Abstract：
BACKGROUND: Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017, with only 14 cases published to date. The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity; however, it appears to be locally aggressive, with no regional or distant metastasis reported to date.
METHODS: We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman, who presented with an indolent right palatal swelling, which progressively increased in size over 7 years. Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed. The patient remained disease free for 4 years following the ablation surgery. Diagnostic workups, treatment, and therapeutic outcomes were discussed.
CONCLUSIONS: More cases are needed to further characterize this entity, understand its biological behavior, and justify the treatment protocols. Resection with wide margins of approximately 1.0 to 1.5 cm is proposed, while neck dissection, post-operative radiotherapy, or chemotherapy are deemed unnecessary.
METHODS: We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman, who presented with an indolent right palatal swelling, which progressively increased in size over 7 years. Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed. The patient remained disease free for 4 years following the ablation surgery. Diagnostic workups, treatment, and therapeutic outcomes were discussed.
CONCLUSIONS: More cases are needed to further characterize this entity, understand its biological behavior, and justify the treatment protocols. Resection with wide margins of approximately 1.0 to 1.5 cm is proposed, while neck dissection, post-operative radiotherapy, or chemotherapy are deemed unnecessary.
摘要：
背景：硬化性牙源性癌是一种罕见的原发性骨内肿瘤，最近在世界卫生组织2017年头颈部肿瘤分类中被列为单一实体，迄今为止仅发表了14例病例。硬化性牙源性癌的生物学特性因其罕见而仍不清楚；然而，它似乎在当地具有侵略性，迄今未报告区域或远处转移。
方法：我们报道了一例62岁女性上颌骨硬化性牙源性癌，表现为无痛的右腭肿胀，在7年内逐渐增加。进行了右上颌次全切除术，手术边缘约1.5cm。患者在消融手术后4年内保持无病。诊断检查,治疗,并讨论了治疗结果。
结论：需要更多病例来进一步表征该实体，了解它的生物学行为，并证明治疗方案的合理性。建议切除约1.0至1.5厘米的宽边缘，而颈部解剖,术后放疗,或化疗被认为是不必要的。
方法：我们报道了一例62岁女性上颌骨硬化性牙源性癌，表现为无痛的右腭肿胀，在7年内逐渐增加。进行了右上颌次全切除术，手术边缘约1.5cm。患者在消融手术后4年内保持无病。诊断检查,治疗,并讨论了治疗结果。
结论：需要更多病例来进一步表征该实体，了解它的生物学行为，并证明治疗方案的合理性。建议切除约1.0至1.5厘米的宽边缘，而颈部解剖,术后放疗,或化疗被认为是不必要的。
