PDF(Pubmed)
Abstract：
UNASSIGNED: This study is designed to assess the pattern of nonadherence, and associated factors among ambulatory patients with epilepsy at Jimma Medical Center, Southwestern Ethiopia, from November 2020 to April 2021.
UNASSIGNED: A hospital-based prospective observational study was employed. A consecutive sampling method was used to recruit study participants. Nonadherence was assessed by the Hill-Bone compliance to the high blood pressure therapy scale. A threshold of 18 scores was used to classify adherence status. Epi-Data manager version 4.6 was used for data entry and all statistical analysis was performed by Statistical Package for Social Science 25.0. Multivariable logistic regression was performed to explore associated factors.
UNASSIGNED: A survey included 334 patients with epilepsy. One hundred twenty-two (36.52%) of the study participants were found to be non-adherent. The factors associated with nonadherence were poor involvement of the patient in the therapeutic decision (adjusted odds ratio = 1.74; 95% confidence interval: 1.04-2.90; p = 0.034), per month income of lesser than1000 Ethiopian birr (adjusted odds ratio = 2.66; 95% confidence interval: 1.03-6.84; p = 0.042), recent seizure episodes (adjusted odds ratio = 1.97; 95% confidence interval: 1.20-3.23; p = 0.007), adverse drug reaction (AOR = 2.13; 95% confidence interval: 1.31-3.47; p = 0.002), and negative medication belief (adjusted odds ratio = 1.28; 95% confidence interval: 1.53-2.25; p = 0.043).
UNASSIGNED: In our setting, the magnitude of nonadherence was substantially high. Hence, providing regular health-related information about the disease and treatment, supplying free antiepileptic drugs, routine assessment of adverse drug reactions, and a multidisciplinary approach involving patients may improve adherence.
UNASSIGNED: A hospital-based prospective observational study was employed. A consecutive sampling method was used to recruit study participants. Nonadherence was assessed by the Hill-Bone compliance to the high blood pressure therapy scale. A threshold of 18 scores was used to classify adherence status. Epi-Data manager version 4.6 was used for data entry and all statistical analysis was performed by Statistical Package for Social Science 25.0. Multivariable logistic regression was performed to explore associated factors.
UNASSIGNED: A survey included 334 patients with epilepsy. One hundred twenty-two (36.52%) of the study participants were found to be non-adherent. The factors associated with nonadherence were poor involvement of the patient in the therapeutic decision (adjusted odds ratio = 1.74; 95% confidence interval: 1.04-2.90; p = 0.034), per month income of lesser than1000 Ethiopian birr (adjusted odds ratio = 2.66; 95% confidence interval: 1.03-6.84; p = 0.042), recent seizure episodes (adjusted odds ratio = 1.97; 95% confidence interval: 1.20-3.23; p = 0.007), adverse drug reaction (AOR = 2.13; 95% confidence interval: 1.31-3.47; p = 0.002), and negative medication belief (adjusted odds ratio = 1.28; 95% confidence interval: 1.53-2.25; p = 0.043).
UNASSIGNED: In our setting, the magnitude of nonadherence was substantially high. Hence, providing regular health-related information about the disease and treatment, supplying free antiepileptic drugs, routine assessment of adverse drug reactions, and a multidisciplinary approach involving patients may improve adherence.
摘要：
■本研究旨在评估不依从性的模式，Jimma医学中心门诊癫痫患者的相关因素，埃塞俄比亚西南部,从2020年11月到2021年4月。
■采用了以医院为基础的前瞻性观察研究。采用连续抽样的方法招募研究参与者。通过Hill-Bone对高血压治疗量表的依从性评估不依从性。18个分数的阈值用于对依从性状态进行分类。Epi-Data管理器4.6版用于数据输入，所有统计分析均由社会科学统计软件包25.0进行。采用多因素logistic回归分析相关因素。
■一项调查包括334名癫痫患者。一百二十二（36.52％）的研究参与者被发现是非粘附性的。与不依从性相关的因素是患者在治疗决策中的参与程度较差（调整后的比值比=1.74；95％置信区间：1.04-2.90；p=0.034），每月收入小于1000埃塞俄比亚比尔(调整后的赔率比=2.66；95%置信区间：1.03-6.84；p=0.042)，近期癫痫发作（调整后的比值比=1.97；95%置信区间：1.20-3.23；p=0.007），药物不良反应（AOR=2.13;95％置信区间：1.31-3.47;p=0.002），和消极的药物信念（调整后的比值比=1.28；95％置信区间：1.53-2.25；p=0.043）。
■在我们的设置中，不依从程度相当高.因此，定期提供有关疾病和治疗的健康相关信息，提供免费的抗癫痫药物，药物不良反应的常规评估，涉及患者的多学科方法可能会提高依从性。
■采用了以医院为基础的前瞻性观察研究。采用连续抽样的方法招募研究参与者。通过Hill-Bone对高血压治疗量表的依从性评估不依从性。18个分数的阈值用于对依从性状态进行分类。Epi-Data管理器4.6版用于数据输入，所有统计分析均由社会科学统计软件包25.0进行。采用多因素logistic回归分析相关因素。
■一项调查包括334名癫痫患者。一百二十二（36.52％）的研究参与者被发现是非粘附性的。与不依从性相关的因素是患者在治疗决策中的参与程度较差（调整后的比值比=1.74；95％置信区间：1.04-2.90；p=0.034），每月收入小于1000埃塞俄比亚比尔(调整后的赔率比=2.66；95%置信区间：1.03-6.84；p=0.042)，近期癫痫发作（调整后的比值比=1.97；95%置信区间：1.20-3.23；p=0.007），药物不良反应（AOR=2.13;95％置信区间：1.31-3.47;p=0.002），和消极的药物信念（调整后的比值比=1.28；95％置信区间：1.53-2.25；p=0.043）。
■在我们的设置中，不依从程度相当高.因此，定期提供有关疾病和治疗的健康相关信息，提供免费的抗癫痫药物，药物不良反应的常规评估，涉及患者的多学科方法可能会提高依从性。
