PDF(Pubmed)
Abstract：
To allow the identification of IgG4-related disease (IgG4-RD) from a subclinical phase as it is important to understand the risk of elevated serum IgG4 levels. We planned to evaluate serum IgG4 levels in the participants of the Nagasaki Islands Study (NaIS), a large-scale health checkup cohort study.
This study included 3,240 individuals who participated in the NaIS between 2016 and 2018 and consented to participate in the study. Serum IgG4, IgG, and IgE levels and human leukocyte antigen (HLA) genotyping results of the NaIS subjects as well as lifestyle habits and peripheral blood test results were analyzed. The magnetic bead panel assay (MBA) and the standard nephelometry immunoassay (NIA) were used to measure serum IgG4 levels. The data were evaluated using multivariate analysis to identify lifestyle and genetic factors associated with elevated serum IgG4 levels.
Serum IgG4 levels measured with the NIA and MBA showed a tight positive correlation between the two groups (correlation coefficient 0.942). The median age of the participants in the NaIS was 69 years [63-77]. The median serum IgG4 level was 30.2 mg/dL [IQR 12.5-59.8]. Overall, 1019 (32.1%) patients had a history of smoking. When the subjects were stratified into three groups based on the smoking intensity (pack-year), the serum IgG4 level was significantly higher among those with a higher smoking intensity. Accordingly, the multivariate analysis identified a significant relationship between smoking status and serum IgG4 elevation.
In this study, smoking was identified as a lifestyle factor correlating positively with elevated serum IgG4 levels.
This study included 3,240 individuals who participated in the NaIS between 2016 and 2018 and consented to participate in the study. Serum IgG4, IgG, and IgE levels and human leukocyte antigen (HLA) genotyping results of the NaIS subjects as well as lifestyle habits and peripheral blood test results were analyzed. The magnetic bead panel assay (MBA) and the standard nephelometry immunoassay (NIA) were used to measure serum IgG4 levels. The data were evaluated using multivariate analysis to identify lifestyle and genetic factors associated with elevated serum IgG4 levels.
Serum IgG4 levels measured with the NIA and MBA showed a tight positive correlation between the two groups (correlation coefficient 0.942). The median age of the participants in the NaIS was 69 years [63-77]. The median serum IgG4 level was 30.2 mg/dL [IQR 12.5-59.8]. Overall, 1019 (32.1%) patients had a history of smoking. When the subjects were stratified into three groups based on the smoking intensity (pack-year), the serum IgG4 level was significantly higher among those with a higher smoking intensity. Accordingly, the multivariate analysis identified a significant relationship between smoking status and serum IgG4 elevation.
In this study, smoking was identified as a lifestyle factor correlating positively with elevated serum IgG4 levels.
摘要：
允许从亚临床阶段鉴定IgG4相关疾病（IgG4-RD），因为了解血清IgG4水平升高的风险很重要。我们计划评估长崎群岛研究（NaIS）参与者的血清IgG4水平，一项大规模的健康体检队列研究。
■该研究包括2016年至2018年期间参加NaIS并同意参加该研究的3,240名个人。血清IgG4、IgG、分析NaIS受试者的IgE水平和人类白细胞抗原（HLA）基因分型结果以及生活习惯和外周血检测结果。磁珠板测定(MBA)和标准比浊法免疫测定(NIA)用于测量血清IgG4水平。使用多变量分析评估数据，以确定与血清IgG4水平升高相关的生活方式和遗传因素。
■用NIA和MBA测量的血清IgG4水平在两组之间显示出紧正相关（相关系数0.942）。NaIS参与者的平均年龄为69岁[63-77]。中位血清IgG4水平为30.2mg/dL[IQR12.5-59.8]。总的来说,1019例（32.1%）患者有吸烟史。当根据吸烟强度（包年）将受试者分为三组时，在吸烟强度较高的人群中,血清IgG4水平显著较高.因此，多变量分析确定吸烟状况与血清IgG4升高之间存在显著关系.
■在这项研究中，吸烟被确定为与血清IgG4水平升高呈正相关的生活方式因素.
■该研究包括2016年至2018年期间参加NaIS并同意参加该研究的3,240名个人。血清IgG4、IgG、分析NaIS受试者的IgE水平和人类白细胞抗原（HLA）基因分型结果以及生活习惯和外周血检测结果。磁珠板测定(MBA)和标准比浊法免疫测定(NIA)用于测量血清IgG4水平。使用多变量分析评估数据，以确定与血清IgG4水平升高相关的生活方式和遗传因素。
■用NIA和MBA测量的血清IgG4水平在两组之间显示出紧正相关（相关系数0.942）。NaIS参与者的平均年龄为69岁[63-77]。中位血清IgG4水平为30.2mg/dL[IQR12.5-59.8]。总的来说,1019例（32.1%）患者有吸烟史。当根据吸烟强度（包年）将受试者分为三组时，在吸烟强度较高的人群中,血清IgG4水平显著较高.因此，多变量分析确定吸烟状况与血清IgG4升高之间存在显著关系.
■在这项研究中，吸烟被确定为与血清IgG4水平升高呈正相关的生活方式因素.
