PDF(Pubmed)
Abstract：
Lichen myxedematosus (LM) is an idiopathic cutaneous mucinosis disorder, and monoclonal gammopathy of undetermined significance (MGUS) is a preneoplastic plasma cell disease with a monoclonal increase in globulin. Patients with LM combined with monoclonal gammopathy are normally diagnosed with scleromyxedema. However, we report a case of generalized papules combined with MGUS in a 78-year-old man who was eventually diagnosed with atypical or intermediate forms of LM because it only involved the skin, and the pathological type was not consistent with scleromyxedema. Few cases of atypical or intermediate forms of LM have been reported, so the course of atypical or intermediate forms of LM is unpredictable. We report the diagnosis and treatment of a case of atypical forms of LM to discuss the current understanding of the disease, hoping to provide a reference for clinical research on this disease.
摘要：
苔藓粘液症（LM）是一种特发性皮肤粘液病，和未知意义的单克隆丙种球蛋白病（MGUS）是一种肿瘤前浆细胞疾病，球蛋白单克隆增加。LM合并单克隆丙种球蛋白病的患者通常被诊断为巩膜水肿。然而,我们报告了一例全身性丘疹合并MGUS的78岁男性，最终被诊断为非典型或中间形式的LM，因为它只累及皮肤，病理类型与巩膜水肿不一致。很少有非典型或中间形式的LM报告，因此，LM的非典型或中间形式的过程是不可预测的。我们报告了一例非典型形式的LM的诊断和治疗，以讨论对该疾病的当前认识，以期为本病的临床研究提供参考。
