PDF(Pubmed)
Abstract：
Acute pancreatitis is an acute inflammatory process of the pancreas that is becoming an increasingly common clinical issue. The most frequent underlying etiologies include gallstones and chronic alcohol use, which account for more than two-thirds of cases. We recently experienced a rare case of acute myeloid leukemia (AML) presenting with recurrent acute pancreatitis, which we later discovered was caused by diffusely infiltrating extramedullary sarcoma in the pancreas. Comprehensive analysis of previous cases of AML presenting as acute pancreatitis suggested involvement of cytogenetic alterations in chromosome 16 in its pathogenesis. Further improvement in management of acute pancreatitis is needed, and clinicians should note that this occasionally fatal condition can be the initial and only manifestation of AML. In practice, prompt initiation of intensive chemotherapy is critical for treating such cases of AML-induced acute pancreatitis.
摘要：
急性胰腺炎是胰腺的急性炎症过程，正成为越来越普遍的临床问题。最常见的潜在病因包括胆结石和长期饮酒，占案件的三分之二以上。我们最近经历了一例罕见的急性髓性白血病（AML），表现为复发性急性胰腺炎，我们后来发现，这是由胰腺弥漫性浸润的髓外肉瘤引起的。对先前表现为急性胰腺炎的AML病例的综合分析表明，其发病机理涉及16号染色体的细胞遗传学改变。需要进一步改善急性胰腺炎的管理，临床医生应注意,这种偶尔致命的情况可能是AML的初始和唯一表现.在实践中,迅速开始强化化疗对于治疗此类AML诱导的急性胰腺炎至关重要.
