Abstract：
OBJECTIVE: The present consensus statement was developed by the GINECOR working group on behalf of the Spanish Society of Radiation Oncology (SEOR). This document provides an up-to-date review of the technical aspects in radiation treatment of vulvar cancer.
METHODS: A two-round modified Delphi study was conducted to reach consensus on the appropriateness of technical aspects of external beam radiotherapy and brachytherapy. Three clinical scenarios were proposed: adjuvant treatment of vulvar cancer, radiation treatment of locally advanced vulvar carcinoma and locoregional recurrences. After the first round, an extensive analysis of current medical literature from peer-reviewed journal was performed to define evidence-based treatment options. In the second round, participants were asked to indicate their level of agreement with the preliminary recommendations according to the GRADE (Grade of Recommendation, Assessment, Development, and Evaluation) criteria, as follows: strongly agree; agree; neither agree nor disagree; disagree and strongly disagree.
RESULTS: The main recommendations on external beam radiotherapy and brachytherapy, both in adjuvant setting and local advanced disease are summarized. Recommendations include treatment technique, treatment volume, and doses in target and organs at-risk. Taking into consideration the different clinical scenarios of recurrent disease, the radiation treatment should be individualized.
CONCLUSIONS: In the absence of robust clinical data, these recommendations may help to select the optimal radiotherapy approach for this relatively rare cancer.
METHODS: A two-round modified Delphi study was conducted to reach consensus on the appropriateness of technical aspects of external beam radiotherapy and brachytherapy. Three clinical scenarios were proposed: adjuvant treatment of vulvar cancer, radiation treatment of locally advanced vulvar carcinoma and locoregional recurrences. After the first round, an extensive analysis of current medical literature from peer-reviewed journal was performed to define evidence-based treatment options. In the second round, participants were asked to indicate their level of agreement with the preliminary recommendations according to the GRADE (Grade of Recommendation, Assessment, Development, and Evaluation) criteria, as follows: strongly agree; agree; neither agree nor disagree; disagree and strongly disagree.
RESULTS: The main recommendations on external beam radiotherapy and brachytherapy, both in adjuvant setting and local advanced disease are summarized. Recommendations include treatment technique, treatment volume, and doses in target and organs at-risk. Taking into consideration the different clinical scenarios of recurrent disease, the radiation treatment should be individualized.
CONCLUSIONS: In the absence of robust clinical data, these recommendations may help to select the optimal radiotherapy approach for this relatively rare cancer.
摘要：
目的：本共识声明由GINECOR工作组代表西班牙放射肿瘤学会（SEOR）制定。本文件提供了外阴癌放射治疗技术方面的最新综述。
方法：进行了两轮改良的Delphi研究，以就外部束放射治疗和近距离放射治疗的技术方面的适当性达成共识。提出了三种临床方案：外阴癌的辅助治疗，局部晚期外阴癌和局部复发的放射治疗。第一轮之后,我们对同行评审杂志的当前医学文献进行了广泛分析,以确定循证治疗方案.在第二轮中,参与者被要求根据等级(推荐等级，评估,发展,和评估)标准，如下:强烈同意；同意；既不同意也不同意；不同意和强烈不同意。
结果：关于外束放射治疗和近距离放射治疗的主要建议，总结了辅助治疗和局部晚期疾病。建议包括治疗技术，治疗体积,目标和危险器官的剂量。考虑到复发性疾病的不同临床情况，放射治疗应个体化。
结论：在缺乏可靠的临床数据的情况下，这些建议可能有助于为这种相对罕见的癌症选择最佳的放射治疗方法.
方法：进行了两轮改良的Delphi研究，以就外部束放射治疗和近距离放射治疗的技术方面的适当性达成共识。提出了三种临床方案：外阴癌的辅助治疗，局部晚期外阴癌和局部复发的放射治疗。第一轮之后,我们对同行评审杂志的当前医学文献进行了广泛分析,以确定循证治疗方案.在第二轮中,参与者被要求根据等级(推荐等级，评估,发展,和评估)标准，如下:强烈同意；同意；既不同意也不同意；不同意和强烈不同意。
结果：关于外束放射治疗和近距离放射治疗的主要建议，总结了辅助治疗和局部晚期疾病。建议包括治疗技术，治疗体积,目标和危险器官的剂量。考虑到复发性疾病的不同临床情况，放射治疗应个体化。
结论：在缺乏可靠的临床数据的情况下，这些建议可能有助于为这种相对罕见的癌症选择最佳的放射治疗方法.
