Abstract：
Cystatin SN, encoded by CST1, belongs to the type 2 (T2) cystatin protein superfamily. In the past decade, several publications have highlighted the association between cystatin SN and inflammatory airway diseases including chronic rhinosinusitis, rhinitis, asthma, chronic obstructive pulmonary disease, and chronic hypersensitivity pneumonitis. It is, therefore, crucial to understand the role of cystatin SN in the wider context of T2 inflammatory diseases. Here, we review the expression of cystatin SN in airway-related diseases with different endotypes. We also emphasize the physiological and pathological roles of cystatin SN. Physiologically, cystatin SN protects host tissues from destructive proteolysis by cysteine proteases present in the external environment or produced via internal dysregulated expression. Pathologically, the secretion of cystatin SN from airway epithelial cells initiates and amplifies T2 immunity and subsequently leads to disease. We further discuss the development of cystatin SN as a T2 immunity marker that can be monitored noninvasively and assist in airway disease management. The discovery, biology, and inhibition capability are also introduced to better understand the role of cystatin SN in airway diseases.
摘要：
胱抑素SN,由CST1编码,属于2型(T2)胱抑素蛋白超家族。在过去的十年里,一些出版物强调了胱抑素SN与包括慢性鼻-鼻窦炎在内的炎性气道疾病之间的关联，鼻炎,哮喘,慢性阻塞性肺疾病,和慢性过敏性肺炎。是的,因此,了解胱抑素SN在更广泛的T2炎症性疾病中的作用至关重要。这里,本文就胱抑素SN在不同基因型气道相关疾病中的表达作一综述。我们还强调了胱抑素SN的生理和病理作用。生理学上,胱抑素SN保护宿主组织免受外部环境中存在的或通过内部失调表达产生的半胱氨酸蛋白酶的破坏性蛋白水解。病理上,从气道上皮细胞分泌胱抑素SN启动并放大T2免疫并随后导致疾病。我们进一步讨论了胱抑素SN作为T2免疫标志物的发展，可以无创监测并协助气道疾病管理。的发现,生物学为了更好地了解胱抑素SN在气道疾病中的作用，还介绍了抑制能力。
