PDF(Pubmed)
Abstract：
UNASSIGNED: The association of sex-specific hormones with coronary computed tomography angiography(CCTA)-based plaque characteristics in women without cardiovascular disease is not well understood. We investigated the association of sex-specific hormones with coronary artery plaque characteristics in a contemporary multiracial cohort with no clinical coronary artery disease (CAD).
UNASSIGNED: In this cross-sectional analysis, we utilized data from 2,325 individuals with no clinical CAD from the Miami Heart (MiHeart) study. Multivariable logistic regression models were used to investigate the association of sex hormones: sex hormone binding globulin (SHBG), dehydroepiandrosterone (DHEA), free and total testosterone, estradiol, with plaque characteristics among women and men.
UNASSIGNED: Of the 1,155 women, 34.2% had any plaque and 3.4% had any high-risk plaque features (HRP) while among men (n = 1170), 63.1% had any plaque and 10.4% had HRP. Among women, estradiol and SHBG were associated with lower odds of any plaque after adjusting for age and race-ethnicity (estradiol OR per SD increase: 0.87, 95%CI: 0.76-0.98; SHBG OR per SD increase: 0.82, 95%CI: 0.72-0.93) but the significance did not persist after adjustment of cardiovascular risk factors. High free testosterone was associated with higher odds of HRP (aOR:3.48, 95%CI:1.07-11.26) but null associations for the other sex hormones with HRP, in the context of limited sample size. Among men, there were no significant associations between sex-specific hormones and plaque or HRP.
UNASSIGNED: Among young to middle-aged women with no clinical CAD, increasing estradiol and SHBG were associated with lower odds of any plaque and higher free testosterone was associated with HRP. Larger cohorts may be needed to validate this.
UNASSIGNED: In this cross-sectional analysis, we utilized data from 2,325 individuals with no clinical CAD from the Miami Heart (MiHeart) study. Multivariable logistic regression models were used to investigate the association of sex hormones: sex hormone binding globulin (SHBG), dehydroepiandrosterone (DHEA), free and total testosterone, estradiol, with plaque characteristics among women and men.
UNASSIGNED: Of the 1,155 women, 34.2% had any plaque and 3.4% had any high-risk plaque features (HRP) while among men (n = 1170), 63.1% had any plaque and 10.4% had HRP. Among women, estradiol and SHBG were associated with lower odds of any plaque after adjusting for age and race-ethnicity (estradiol OR per SD increase: 0.87, 95%CI: 0.76-0.98; SHBG OR per SD increase: 0.82, 95%CI: 0.72-0.93) but the significance did not persist after adjustment of cardiovascular risk factors. High free testosterone was associated with higher odds of HRP (aOR:3.48, 95%CI:1.07-11.26) but null associations for the other sex hormones with HRP, in the context of limited sample size. Among men, there were no significant associations between sex-specific hormones and plaque or HRP.
UNASSIGNED: Among young to middle-aged women with no clinical CAD, increasing estradiol and SHBG were associated with lower odds of any plaque and higher free testosterone was associated with HRP. Larger cohorts may be needed to validate this.
摘要：
■在没有心血管疾病的女性中，性别特异性激素与基于冠状动脉CT血管造影（CCTA）的斑块特征之间的关系尚不清楚。我们在没有临床冠状动脉疾病（CAD）的当代多种族队列中调查了性别特异性激素与冠状动脉斑块特征的关系。
■在此横截面分析中，我们利用了来自迈阿密心脏(MiHeart)研究的2,325例无临床CAD患者的数据.采用多变量logistic回归模型研究性激素的相关性:性激素结合球蛋白(SHBG),脱氢表雄酮（DHEA），免费和总睾酮，雌二醇,具有女性和男性的斑块特征。
■在1,155名女性中，34.2%有任何斑块，3.4%有任何高危斑块特征（HRP），而男性（n=1170），63.1%有任何斑块，10.4%有HRP。在女性中,在校正年龄和种族因素后,雌二醇和SHBG与较低的斑块形成几率相关(雌二醇OR每SD增加:0.87,95CI:0.76~0.98;SHBGOR每SD增加:0.82,95CI:0.72~0.93),但在校正心血管危险因素后,显著性没有持续.高游离睾酮与较高的HRP几率相关（aOR：3.48，95CI：1.07-11.26），但其他性激素与HRP的关联无效，在样本量有限的情况下。在男性中,性别特异性激素与斑块或HRP之间无显著关联.
■在没有临床CAD的年轻至中年女性中，雌二醇和SHBG升高与出现斑块的几率较低相关,游离睾酮升高与HRP相关.可能需要更大的队列来验证这一点。
■在此横截面分析中，我们利用了来自迈阿密心脏(MiHeart)研究的2,325例无临床CAD患者的数据.采用多变量logistic回归模型研究性激素的相关性:性激素结合球蛋白(SHBG),脱氢表雄酮（DHEA），免费和总睾酮，雌二醇,具有女性和男性的斑块特征。
■在1,155名女性中，34.2%有任何斑块，3.4%有任何高危斑块特征（HRP），而男性（n=1170），63.1%有任何斑块，10.4%有HRP。在女性中,在校正年龄和种族因素后,雌二醇和SHBG与较低的斑块形成几率相关(雌二醇OR每SD增加:0.87,95CI:0.76~0.98;SHBGOR每SD增加:0.82,95CI:0.72~0.93),但在校正心血管危险因素后,显著性没有持续.高游离睾酮与较高的HRP几率相关（aOR：3.48，95CI：1.07-11.26），但其他性激素与HRP的关联无效，在样本量有限的情况下。在男性中,性别特异性激素与斑块或HRP之间无显著关联.
■在没有临床CAD的年轻至中年女性中，雌二醇和SHBG升高与出现斑块的几率较低相关,游离睾酮升高与HRP相关.可能需要更大的队列来验证这一点。
