PDF(Pubmed)
Abstract：
Following the discovery of Eimeria kongi, we investigated the pathogenicity, immunogenicity, endogenous development and drug sensitivity of this coccidian. Coccidia-free rabbits were inoculated with 1 × 102 to 5 × 104 sporulated oocysts of E. kongi before challenge 14 days post inoculation. E. kongi was moderately pathogenic and induced good immunity against re-infection. All inoculated doses results in reduced food intake and body weight gain, and an inoculation oocyst dose of 1 × 103 or higher caused various degrees of diarrhea. Except for one death of the highest dose group, all rabbits recovered 12 days post inoculation. An inoculation dose of 1 × 103 or 1 × 104 oocysts conferred the most effective protection from re-infection, which reduced oocyst output by approximately 99% and maintained body weight gain. Four generations of schizogony were observed, and the endogenous development mainly occurred in the jejunum and ileum of rabbits. E. kongi was most sensitive to sulfachloropyrazine sodium, followed by decoquinate; it is resistant to diclazuril. Both decoquinate and sulfachloropyrazine sodium may be effective in the control of E. kongi infection.
摘要：
在发现艾美球虫kongi之后，我们调查了致病性，免疫原性,这种球虫的内源性发育和药物敏感性。在接种后14天的攻击之前，将无球虫的兔子接种1×102至5×104个孢子形成的孔虫卵囊。E.kongi具有中等致病性，对再感染具有良好的免疫力。所有接种剂量导致食物摄入量减少和体重增加，1×103或更高的接种卵囊剂量引起不同程度的腹泻。除了最高剂量组的一个死亡，所有兔子在接种后12天恢复。接种剂量为1×103或1×104的卵囊可提供最有效的保护，防止再感染。这减少了约99%的卵囊输出和保持体重增加。观察到四代分裂，内源性发育主要发生在兔的空肠和回肠。E.kongi对磺胺氯吡嗪钠最敏感，其次是脱草铵；它对diclazuril具有抗性。脱喹酸盐和磺胺氯吡嗪钠均可有效控制E.kongi感染。
