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Abstract：
UNASSIGNED: To investigate the association between the 2 acute phase proteins, C-reactive protein (CRP) and pentraxin 3 (PTX3) with central serous chorioretinopathy (CSCR), as PTX3 is a glucocorticoid-induced protein.
UNASSIGNED: Cross-sectional multicenter study.
UNASSIGNED: Patients with CSCR compared with age- and sex-matched healthy participants.
UNASSIGNED: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.
UNASSIGNED: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.
UNASSIGNED: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.
UNASSIGNED: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.
UNASSIGNED: The author(s) have no proprietary or commercial interest in any materials discussed in this article.
UNASSIGNED: Cross-sectional multicenter study.
UNASSIGNED: Patients with CSCR compared with age- and sex-matched healthy participants.
UNASSIGNED: Patients with CSCR from 3 centers in Europe were included in the study. The clinical form of CSCR was recorded. Blood samples from patients with CSCR and healthy participants were sampled, and high-sensitivity CRP and PTX3 levels were measured in the serum.
UNASSIGNED: C-reactive protein and PTX3 serum level comparison between patients with CSCR with age- and sex-matched healthy participants.
UNASSIGNED: Although CRP levels were higher in patients with CSCR (n = 216) than in age- and sex-matched controls (n = 130) (2.2 ± 3.2 mg/l vs. 1.5 mg/l ± 1.4, respectively, P = 0.037), PTX3 levels were lower in patients with CSCR (10.5 ± 19.9 pg/ml vs. 87.4 ± 73.2 pg/ml, respectively, P < 0.001). There was no significant difference in CRP or PTX3 levels between patients with acute/recurrent and chronic CSCR.
UNASSIGNED: In patients with CSCR, high CRP and low PTX3 levels suggest a form of low-grade systemic inflammation together with a lack of glucocorticoid pathway activation, raising new hypotheses on the pathophysiology of CSCR.
UNASSIGNED: The author(s) have no proprietary or commercial interest in any materials discussed in this article.
摘要：
■为了研究两种急性期蛋白之间的关联，C反应蛋白（CRP）和正五聚蛋白3（PTX3）与中心性浆液性脉络膜视网膜病变（CSCR），因为PTX3是糖皮质激素诱导的蛋白质。
■横断面多中心研究。
■CSCR患者与年龄和性别匹配的健康参与者相比。
■来自欧洲3个中心的CSCR患者纳入研究。记录CSCR的临床形式。对CSCR患者和健康参与者的血液样本进行采样，检测血清中高敏CRP和PTX3水平。
■CSCR患者与年龄和性别匹配的健康参与者之间的C反应蛋白和PTX3血清水平比较。
■尽管CSCR患者的CRP水平（n=216）高于年龄和性别匹配的对照组（n=130）（2.2±3.2mg/lvs.分别为1.5mg/l±1.4，P=0.037),CSCR患者的PTX3水平较低（10.5±19.9pg/ml与87.4±73.2pg/ml，分别,P<0.001)。急性/复发和慢性CSCR患者之间的CRP或PTX3水平没有显着差异。
■在患有CSCR的患者中，高CRP和低PTX3水平提示一种低度全身炎症，同时缺乏糖皮质激素途径激活，提出了关于CSCR病理生理学的新假设。
■作者对本文讨论的任何材料都没有专有或商业利益。
■横断面多中心研究。
■CSCR患者与年龄和性别匹配的健康参与者相比。
■来自欧洲3个中心的CSCR患者纳入研究。记录CSCR的临床形式。对CSCR患者和健康参与者的血液样本进行采样，检测血清中高敏CRP和PTX3水平。
■CSCR患者与年龄和性别匹配的健康参与者之间的C反应蛋白和PTX3血清水平比较。
■尽管CSCR患者的CRP水平（n=216）高于年龄和性别匹配的对照组（n=130）（2.2±3.2mg/lvs.分别为1.5mg/l±1.4，P=0.037),CSCR患者的PTX3水平较低（10.5±19.9pg/ml与87.4±73.2pg/ml，分别,P<0.001)。急性/复发和慢性CSCR患者之间的CRP或PTX3水平没有显着差异。
■在患有CSCR的患者中，高CRP和低PTX3水平提示一种低度全身炎症，同时缺乏糖皮质激素途径激活，提出了关于CSCR病理生理学的新假设。
■作者对本文讨论的任何材料都没有专有或商业利益。
