Abstract：
BACKGROUND: Since cancer development is inevitable in patients with familial adenomatous polyposis (FAP), we aimed to determine the incidence of incidental malignancy in prophylactic colectomy specimens.
METHODS: The files of patients who underwent prophylactic surgery for FAP between 2010 and 2020 were retrospectively reviewed. The incidence of incidental malignancy in histopathological specimens was examined and a comprehensive literature review was made.
RESULTS: Fifty-five patients were included in the study, of whom 30 patients had a diagnosis of primary malignancy. Prophylactic colectomy was performed on 25 patients. The pathology results indicated that the specimens were benign in 12 patients (48%) and revealed carcinoma in situ in 11 patients (44%). Incidental malignancy was detected in 2 patients (8%). In the literature review, there were 243 patients who underwent prophylactic colectomy and incidental cancer was detected in 25 patients (10.3%) with the stages of 1 (7.4%), 2 (2.1%), and 3 (0.8%), respectively.
CONCLUSIONS: Incidental cancer is not rare in patients who have undergone prophylactic colectomy for FAP. Hopefully. they are usually at early stages and unexpected advanced cancers are seen rarely.
METHODS: The files of patients who underwent prophylactic surgery for FAP between 2010 and 2020 were retrospectively reviewed. The incidence of incidental malignancy in histopathological specimens was examined and a comprehensive literature review was made.
RESULTS: Fifty-five patients were included in the study, of whom 30 patients had a diagnosis of primary malignancy. Prophylactic colectomy was performed on 25 patients. The pathology results indicated that the specimens were benign in 12 patients (48%) and revealed carcinoma in situ in 11 patients (44%). Incidental malignancy was detected in 2 patients (8%). In the literature review, there were 243 patients who underwent prophylactic colectomy and incidental cancer was detected in 25 patients (10.3%) with the stages of 1 (7.4%), 2 (2.1%), and 3 (0.8%), respectively.
CONCLUSIONS: Incidental cancer is not rare in patients who have undergone prophylactic colectomy for FAP. Hopefully. they are usually at early stages and unexpected advanced cancers are seen rarely.
摘要：
背景：由于家族性腺瘤性息肉病（FAP）患者的癌症发展是不可避免的，我们旨在确定预防性结肠切除术标本中偶发恶性肿瘤的发生率.
方法：回顾性分析2010年至2020年期间接受FAP预防性手术的患者的资料。检查了组织病理学标本中偶发恶性肿瘤的发生率，并进行了全面的文献综述。
结果：55名患者被纳入研究，其中30例患者被诊断为原发性恶性肿瘤。对25例患者进行了预防性结肠切除术。病理结果显示12例(48%)为良性,11例(44%)为原位癌。在2例患者中发现了偶然的恶性肿瘤（8％）。在文献综述中,有243例接受预防性结肠切除术的患者，在25例（10.3％）中发现了偶发癌症，分期为1（7.4％），2（2.1%），和3（0.8％），分别。
结论：在FAP行预防性结肠切除术的患者中，偶发癌症并不罕见。希望如此。它们通常处于早期阶段，很少见到意外的晚期癌症。
方法：回顾性分析2010年至2020年期间接受FAP预防性手术的患者的资料。检查了组织病理学标本中偶发恶性肿瘤的发生率，并进行了全面的文献综述。
结果：55名患者被纳入研究，其中30例患者被诊断为原发性恶性肿瘤。对25例患者进行了预防性结肠切除术。病理结果显示12例(48%)为良性,11例(44%)为原位癌。在2例患者中发现了偶然的恶性肿瘤（8％）。在文献综述中,有243例接受预防性结肠切除术的患者，在25例（10.3％）中发现了偶发癌症，分期为1（7.4％），2（2.1%），和3（0.8％），分别。
结论：在FAP行预防性结肠切除术的患者中，偶发癌症并不罕见。希望如此。它们通常处于早期阶段，很少见到意外的晚期癌症。
