Abstract：
Mycobiota are essential to the health of any living being, creating a balanced and complex interaction between bacteria, the immune system, and the tissue cells of the host. Talaromyces marneffei (also known as Penicillium marneffei) is a dimorphic fungus, endemic in South Asia, which often causes a life-threatening systemic fungal infection (called penicilliosis), particularly in immunocompromised hosts. Nasal swabs from 73 healthy volunteers were analysed to characterize their mycobiota, through its cultural characteristics, morphology, and molecular methods (PCR). All volunteers were also asked to answer to an anonymous questionnaire. Three women were positive (and asymptomatic) for T. marneffei. One of them was reported to have lupus. This study contributes to improving our knowledge about human normal mycobiota, identifying mycotic agents that may cause complicated systemic infections (as T. marneffei), especially in immunosuppressed patients, as well as other possible risk factors of exposure or prognosis.
• Talaromyces marneffei is a zoonotic fungus that may be responsible for life-threatening systemic infections in immune-comprised patients. • Talaromyces marneffei was identified in nasal swabs from asymptomatic volunteers. • This suggests that this fungus may be part of the nasal normal mycobiota of some humans.
• Talaromyces marneffei is a zoonotic fungus that may be responsible for life-threatening systemic infections in immune-comprised patients. • Talaromyces marneffei was identified in nasal swabs from asymptomatic volunteers. • This suggests that this fungus may be part of the nasal normal mycobiota of some humans.
摘要：
分枝杆菌对任何生物的健康都至关重要，在细菌之间建立平衡而复杂的相互作用，免疫系统和宿主的组织细胞。马尔尼菲塔拉酵母（也称为马尔尼菲青霉菌）是一种双态真菌，南亚的地方病，通常会导致危及生命的全身性真菌感染（称为青霉病），特别是在免疫受损的宿主中。对73名健康志愿者的鼻拭子进行了分析，以表征他们的分枝杆菌群，通过其文化特征，形态学和分子方法（PCR）。还要求所有志愿者回答匿名问卷。三名妇女的马尔尼菲氏杆菌呈阳性（无症状）。据报道，其中一人患有狼疮。这项研究有助于提高我们对人类正常分枝杆菌的认识，确定可能导致复杂的全身性感染的霉菌制剂（如马尔尼菲T.），尤其是在免疫抑制患者中，以及其他可能的暴露风险因素或预后。
T.marneffei是一种人畜共患真菌，可能是危及免疫患者生命的全身性感染的原因。在无症状志愿者的鼻拭子中发现了马尼菲T.这表明这种真菌可能是某些人的鼻正常分枝杆菌群的一部分。
T.marneffei是一种人畜共患真菌，可能是危及免疫患者生命的全身性感染的原因。在无症状志愿者的鼻拭子中发现了马尼菲T.这表明这种真菌可能是某些人的鼻正常分枝杆菌群的一部分。
