Abstract：
BACKGROUND: Ceramide synthases (CERSes) are also known longevity assurance (LASS) genes. CERSes play important roles in the regulation of cancer progression. The CERS family is expressed in a variety of human tumours and is involved in tumorigenesis. They are closely associated with the progression of liver, breast, cervical, ovarian, colorectal, head and neck squamous cell, gastric, lung, prostate, oesophageal, pancreatic and blood cancers. CERSes play diverse and important roles in the regulation of cell survival, proliferation, apoptosis, migration, invasion, and drug resistance. The differential expression of CERSes in tumour and nontumour cells and survival analysis of cancer patients suggest that some CERSes could be used as potential prognostic markers. They are also important potential targets for cancer therapy.
METHODS: In this review, we summarize the available evidence on the inhibitory or promotive roles of CERSes in the progression of many cancers. Furthermore, we summarize the identified upstream and downstream molecular mechanisms that may regulate the function of CERSes in cancer settings.
METHODS: In this review, we summarize the available evidence on the inhibitory or promotive roles of CERSes in the progression of many cancers. Furthermore, we summarize the identified upstream and downstream molecular mechanisms that may regulate the function of CERSes in cancer settings.
摘要：
背景：神经酰胺合酶（CERSes）也是已知的长寿保证（LASS）基因。CERSes在调节癌症进展中起重要作用。CERS家族在多种人类肿瘤中表达并参与肿瘤发生。它们与肝脏的进展密切相关，乳房,子宫颈,卵巢,结直肠,头颈部鳞状细胞,胃,肺，前列腺,食道,胰腺癌和血癌.CERSes在细胞存活的调节中起着多样化和重要的作用,扩散,凋亡，迁移,入侵,和抗药性。CERSes在肿瘤和非肿瘤细胞中的差异表达以及癌症患者的生存分析表明，某些CERSes可用作潜在的预后标志物。它们也是癌症治疗的重要潜在靶标。
方法：在这篇综述中，我们总结了CERSes在许多癌症进展中的抑制或促进作用的现有证据.此外，我们总结了确定的可能在癌症环境中调节CERSes功能的上游和下游分子机制。
方法：在这篇综述中，我们总结了CERSes在许多癌症进展中的抑制或促进作用的现有证据.此外，我们总结了确定的可能在癌症环境中调节CERSes功能的上游和下游分子机制。
