UNASSIGNED: A PubMed, Cochrane Library, Medline, and Ovid search from inception to October 2022 provided articles relating to MM pathophysiology and treatment.
UNASSIGNED: In patients for whom standard acute therapy is inadequate, short term or daily preventive treatment should be considered. Patients with PMM may be adequately managed with short term preventive treatment started 2 days prior to the onset of migraine and continued for 5-6 days. Frovatriptan is the mainstay of short-term prevention. Patients who experience additional attacks outside the menstrual period may benefit from daily preventive treatment. Estrogen-containing contraceptive treatment may be effective in appropriately selected patients. Emerging research on the pathophysiology of MM indicates that oxytocin agonists and CGRP antagonists may prove to be effective treatment options.
■APubMed,科克伦图书馆,Medline,从开始到2022年10月的Ovid搜索提供了有关MM病理生理学和治疗的文章。
■在标准急性治疗不足的患者中,应考虑短期或每日预防性治疗。PMM患者可以在偏头痛发作前2天开始短期预防性治疗并持续5-6天。Frovatriptan是短期预防的支柱。在月经期以外经历额外发作的患者可能会从日常预防治疗中受益。含雌激素的避孕治疗对适当选择的患者可能有效。关于MM的病理生理学的新兴研究表明催产素激动剂和CGRP拮抗剂可能被证明是有效的治疗选择。