Abstract：
Cell adhesion molecule 1 (CADM1) is one of the immunoglobulin super family adhesion molecules, that is proposed to contribute in the pathogenesis of various types of cutaneous T-cell lymphoma, including mycosis fungoides (MF). In this work, we decided to examine the immunohistochemical expression of CADM1 in MF specimens compared to premycotic parapsoriasis, benign inflammatory dermatosis and normal control skin specimens. 125 participants were enrolled (50 MF, 25 parapsoriasis, 25 inflammatory dermatosis, and 25 healthy controls). Patients were selected from the Outpatient Clinic of Dermatology and Venereology Department, Tanta University Hospitals. From all, 4 mm punch skin biopsies were taken and examined for CADM1 immunohistochemical expression. The current study revealed statistically significant upregulation of CADM1 expression in MF specimens in comparison to parapsoriasis, inflammatory dermatosis, and normal control specimens. Additionally, there was statistically significant positive correlation between CADM1 expression and progression of TNMB staging of MF disease. Therefore, it is possible to recommend CADM1 as a beneficial diagnostic immunohistochemical marker for differentiation between early stages of MF and both the premycotic parapsoriasis and benign inflammatory dermatosis. Moreover, it may be of value in early detection of neoplastic transformation of parapsoriasis as well as in assessment of MF progression.
摘要：
细胞粘附分子1(CADM1)是免疫球蛋白超家族粘附分子之一,这被认为有助于各种类型的皮肤T细胞淋巴瘤的发病机理，包括霉菌病（MF）。在这项工作中,我们决定检测MF标本中CADM1的免疫组织化学表达与霉菌性副银屑病相比，良性炎症性皮肤病和正常对照皮肤标本。125名参与者被登记(50MF，25副牛皮癣，25炎性皮肤病，和25个健康对照)。患者来自皮肤性病科门诊，坦塔大学医院。从所有,取4mm穿孔皮肤活检并检查CADM1免疫组织化学表达。当前的研究显示，与银屑病副相比，MF标本中CADM1表达的统计学意义上的上调，炎症性皮肤病，和正常对照标本。此外,CADM1表达与MF病TNMB分期进展呈显著正相关。因此,有可能推荐CADM1作为一种有益的诊断免疫组织化学标志物,用于区分MF的早期阶段以及霉菌性副银屑病和良性炎症性皮肤病.此外，它可能在早期发现银屑病副的肿瘤转化以及评估MF进展方面有价值。
