PDF(Pubmed)
Abstract：
Animal models for studying human pathogens are crucially lacking. We describe the implantation in mice of engineered human mature microvasculature consisting of endothelial and perivascular cells embedded in collagen hydrogel that allows investigation of pathogen interactions with the endothelium, including in vivo functional studies. Using Neisseria meningitidis as a paradigm of human-restricted infection, we demonstrated the strength and opportunities associated with the use of this approach.
摘要：
严重缺乏用于研究人类病原体的动物模型。我们描述了在小鼠中植入工程化的人类成熟微脉管系统，该系统由嵌入胶原水凝胶中的内皮和血管周围细胞组成，可以研究病原体与内皮的相互作用。包括体内功能研究。使用脑膜炎奈瑟菌作为人类限制性感染的范例，我们展示了与使用这种方法相关的力量和机会。
