PDF(Pubmed)
Abstract：
Clostridium paraputrificum (C. paraputrificum) is clinically important due to its association with underlying medical conditions. Infection with C. paraputrificum may worsen HIV prognosis, leading to acquired immunodeficiency syndrome. However, it is not frequently isolated and its susceptibility to antibiotics has not been well studied. Our report examines the case of a patient with human immunodeficiency virus (HIV) infection, who was diagnosed with Clostridium paraputrificum bacteremia. A 59-year-old male was admitted to hospital with a medical history of human immunodeficiency virus (HIV), hepatitis C virus (HCV), and neck pain. Following episodes of high fever, the patient received a full work up to test for sepsis. Blood culture revealed bacterial growth, and MALDI-TOF mass spectrometry confirmed the diagnosis of Clostridium paraputrificum bacteremia. The patient received treatment with meropenem and vancomycin antibiotics, which cleared the infection after 48 hours; however, inflammatory markers remained high. To date, a limited number of reported cases of C. paraputrificum exist; thus, this case report contributes valuable information to the literature to improve our understanding of its action and resistance profiles and aid future bacteremia management.
摘要：
副营养梭菌(C.副营养）由于与潜在的医疗状况有关而在临床上很重要。副营养梭菌感染可能使HIV预后恶化，导致获得性免疫缺陷综合征.然而,它不经常被分离，对抗生素的敏感性也没有得到很好的研究。我们的报告检查了人类免疫缺陷病毒（HIV）感染患者的病例，被诊断为副营养梭状芽胞杆菌菌血症。一名59岁男性因人类免疫缺陷病毒(HIV)病史入院,丙型肝炎病毒（HCV），颈部疼痛。高烧发作后，患者接受了全面检查以检查败血症。血培养显示细菌生长,MALDI-TOF质谱证实副营养梭菌菌血症的诊断。患者接受美罗培南和万古霉素抗生素治疗，它在48小时后清除了感染；然而，炎症标志物仍然很高。迄今为止,报告的副营养梭菌病例数量有限；因此，本病例报告为文献提供了有价值的信息,以提高我们对其作用和耐药谱的理解,并有助于未来的菌血症管理.
