PDF(Pubmed)
Abstract：
With the development trend of an aging society, Alzheimer\'s disease (AD) has become an urgent problem in the field of medicine worldwide. Cognitive impairment in AD patients leads to a decline in the ability to perform daily living and abnormalities in behavior and personality, causing abnormal psychiatric symptoms, which seriously affect the daily life of patients. Currently, mainly drug therapy is used for AD patients in the clinic, but a large proportion of patients will experience drug efficacy not working, and even some drugs bring severe sleep disorders. Acupuncture, with its unique concept and treatment method, has been validated through a large number of experiments and proved its reliability of acupuncture in the treatment of AD. Many advances have been made in the study of the neurobiological mechanisms of acupuncture in the treatment of AD, further demonstrating the good efficacy and unique advantages of acupuncture in the treatment of AD. This review first summarizes the pathogenesis of AD and then illustrates the research progress of acupuncture in the treatment of AD, which includes the effect of acupuncture on the changes of biochemical indicators in AD in vivo and the specific mechanism of action to exert the therapeutic effect. Changes in relevant indicators of AD similarly further validate the effectiveness of acupuncture treatment. The clinical and mechanistic studies of acupuncture in the treatment of AD are intensified to fit the need for social development. It is believed that acupuncture will achieve new achievements in the treatment of AD as research progresses.
摘要：
随着老龄化社会的发展趋势,阿尔茨海默病(Alzheimer’sdisease,AD)已成为全球医学领域亟待解决的问题。AD患者的认知障碍导致日常生活能力下降，行为和人格异常，导致异常的精神症状，严重影响患者的日常生活。目前,临床上主要用于AD患者的药物治疗,但是很大一部分患者会经历药物功效不起作用，甚至有些药物会带来严重的睡眠障碍。针灸,以其独特的概念和治疗方法，经大量实验验证,证明了针刺治疗AD的可靠性。针灸治疗AD的神经生物学机制研究取得了许多进展，进一步证明了针灸治疗AD的良好疗效和独特优势。本文首先对AD的发病机制进行综述,然后阐述针灸治疗AD的研究进展,包括针刺对AD体内生化指标变化的影响及发挥治疗作用的具体作用机制。AD相关指标的变化同样进一步验证了针刺治疗的有效性。针灸治疗AD的临床和机理研究正在加强，以适应社会发展的需要。相信随着研究的进展,针灸治疗AD将取得新的成果。
