羟基酪醇通过改善脂肪变性减轻乙醇诱导的肝损伤 ,氧化应激和肝脏炎症通过干扰 STAT3 / iNOS 通路。
关键词: ADH, alcohol dehydrogenase ALD, alcohol liver disease ALDH, acetaldehyde dehydrogenase ALT, alanine aminotransferase AST, aspartate aminotransferase CAT, catalase COX2, cyclo-oxygen-ase2 CYP2E1, cytochrome P450 2E1 DMSO, Dimethyl sulfoxide DPPH, 2,2-Diphenyl-1-picrylhydrazyl FASN, fatty acid synthase GSH, glutathione HT, hydroxytyrosol HepG2 Hepatic steatosis Hydroxytyrosol LDL, low density lipoprotein LPS, lipopolysaccharides Liver injury MDA, malondialdehyde NO, nitric oxide PPAR-γ, peroxisome proliferators-activated receptor ROS, reactive oxygen species SREBP-1c, sterol regulatory element-binding protein-1c STAT3, signal transducer and activator of transcription 3 STAT3/iNOS pathway TC, total cholesterol TG, triglyceride alcoholic liver disease anti-inflammation anti-oxidation iNOS, inducible nitric oxide Synthas
Mesh : Animals Mice Ethanol / toxicity metabolism Chemical and Drug Induced Liver Injury, Chronic / metabolism Mice, Inbred C57BL Fatty Liver / drug therapy metabolism Liver Liver Diseases, Alcoholic / drug therapy metabolism Oxidative Stress Inflammation / chemically induced drug therapy metabolism Glutathione / metabolism
来 源: DOI:10.1080/13510002.2023.2187564