PDF(Pubmed)
Abstract：
BACKGROUND: Basaloid neoplasms of the sinonasal tract represent a significant group of tumors with histological overlap but often with different etiologies (i.e., viral, genetics), clinical management, and prognostic significance.
METHODS: Review.
RESULTS: \"Basaloid\" generally refers to cells with coarse chromatin in round nuclei and sparse cytoplasm, resembling cells of epithelial basal layers or imparting an \"immature\" appearance. Tumors with this characteristic in the sinonasal tract are represented by a spectrum of benign to high-grade malignant neoplasms, such as adenoid cystic carcinoma, NUT carcinoma, sinonasal undifferentiated carcinoma, SWI/SNF complex-deficient carcinomas, and adamantinoma-like Ewing sarcoma.
CONCLUSIONS: In some instances, histology alone may be sufficient for diagnosis. However, limited biopsy material or fine-needle aspiration specimens may be particularly challenging. Therefore, often other diagnostic procedures, including a combination of histology, immunohistochemistry (IHC), DNA and RNA testing, and molecular genetics are necessary to establish an accurate diagnosis.
METHODS: Review.
RESULTS: \"Basaloid\" generally refers to cells with coarse chromatin in round nuclei and sparse cytoplasm, resembling cells of epithelial basal layers or imparting an \"immature\" appearance. Tumors with this characteristic in the sinonasal tract are represented by a spectrum of benign to high-grade malignant neoplasms, such as adenoid cystic carcinoma, NUT carcinoma, sinonasal undifferentiated carcinoma, SWI/SNF complex-deficient carcinomas, and adamantinoma-like Ewing sarcoma.
CONCLUSIONS: In some instances, histology alone may be sufficient for diagnosis. However, limited biopsy material or fine-needle aspiration specimens may be particularly challenging. Therefore, often other diagnostic procedures, including a combination of histology, immunohistochemistry (IHC), DNA and RNA testing, and molecular genetics are necessary to establish an accurate diagnosis.
摘要：
背景：鼻窦基底动脉样肿瘤代表了一组重要的肿瘤，具有组织学重叠，但通常具有不同的病因（即，病毒，遗传学），临床管理，和预后意义。
方法：审查。
结果：“Basaloid”通常是指圆形细胞核中染色质粗糙，细胞质稀疏的细胞，类似上皮基底层的细胞或赋予“不成熟”外观。在鼻窦具有这种特征的肿瘤表现为一系列良性至高级恶性肿瘤，如腺样囊性癌，NUT癌，鼻窦未分化癌,SWI/SNF复合物缺陷癌，和金刚烷胺瘤样尤因肉瘤.
结论：在某些情况下，仅组织学可能足以诊断。然而,有限的活检材料或细针抽吸标本可能特别具有挑战性。因此,通常是其他诊断程序，包括组织学的组合，免疫组织化学（IHC），DNA和RNA检测,和分子遗传学是建立准确诊断所必需的。
方法：审查。
结果：“Basaloid”通常是指圆形细胞核中染色质粗糙，细胞质稀疏的细胞，类似上皮基底层的细胞或赋予“不成熟”外观。在鼻窦具有这种特征的肿瘤表现为一系列良性至高级恶性肿瘤，如腺样囊性癌，NUT癌，鼻窦未分化癌,SWI/SNF复合物缺陷癌，和金刚烷胺瘤样尤因肉瘤.
结论：在某些情况下，仅组织学可能足以诊断。然而,有限的活检材料或细针抽吸标本可能特别具有挑战性。因此,通常是其他诊断程序，包括组织学的组合，免疫组织化学（IHC），DNA和RNA检测,和分子遗传学是建立准确诊断所必需的。
