PDF(Pubmed)
Abstract：
UNASSIGNED: Low-dose ephedrine and ketamine may accelerate the onset time of action of neuromuscular blocking agents. We studied the effect of ephedrine and ketamine and cisatracurium priming on endotracheal intubation conditions and the onset time of action of cisatracurium.
UNASSIGNED: The study was a double-blind clinical trial performed on American Society of Anesthesiologists (ASA) class 1 and 2 patients, who were candidates for general anesthesia. In total, 120 patients were entered into the study and were divided into 4 groups, E, K, E + K, and N. The first group was given 70 mcg/kg ephedrine (E group), the second group was given 0.5 ml/kg ketamine (K group), the third group was given the same amount of ketamine plus ephedrine (E + K group), and the fourth group was given the same volume of normal saline (control group); a single dose of 0.1 mg/kg cisatracurium was given, and intubating conditions were evaluated at 60 seconds after cisatracurium administration.
UNASSIGNED: The mean Cooper score based on the response to laryngoscopy, the position of the vocal cords, and the movement of the diaphragm of patients in the control group with a mean of 2.53 ± 1.07 was significantly lower than in the three groups of E, K, and E + K with the means of 4.47. 1.17, 4.53 ± 1.14, and 7.63 ± 1.42, respectively (P value < 0.001). In the (E + K) group, it was significantly higher than in the two other drugs alone (P value < 0.001). The two groups of E and K alone were not significantly different from each other (P value = 0.997). The means of hemodynamic parameters were not significantly different in any of the groups (P value > 0.05).
UNASSIGNED: According to the results of the present study, the use of low-dose ephedrine and ketamine alone can improve intubation conditions. In addition, the combined use of these drugs not only had any Positive effect on patients\' hemodynamic parameters but also greatly improved intubation conditions.
UNASSIGNED: The study was a double-blind clinical trial performed on American Society of Anesthesiologists (ASA) class 1 and 2 patients, who were candidates for general anesthesia. In total, 120 patients were entered into the study and were divided into 4 groups, E, K, E + K, and N. The first group was given 70 mcg/kg ephedrine (E group), the second group was given 0.5 ml/kg ketamine (K group), the third group was given the same amount of ketamine plus ephedrine (E + K group), and the fourth group was given the same volume of normal saline (control group); a single dose of 0.1 mg/kg cisatracurium was given, and intubating conditions were evaluated at 60 seconds after cisatracurium administration.
UNASSIGNED: The mean Cooper score based on the response to laryngoscopy, the position of the vocal cords, and the movement of the diaphragm of patients in the control group with a mean of 2.53 ± 1.07 was significantly lower than in the three groups of E, K, and E + K with the means of 4.47. 1.17, 4.53 ± 1.14, and 7.63 ± 1.42, respectively (P value < 0.001). In the (E + K) group, it was significantly higher than in the two other drugs alone (P value < 0.001). The two groups of E and K alone were not significantly different from each other (P value = 0.997). The means of hemodynamic parameters were not significantly different in any of the groups (P value > 0.05).
UNASSIGNED: According to the results of the present study, the use of low-dose ephedrine and ketamine alone can improve intubation conditions. In addition, the combined use of these drugs not only had any Positive effect on patients\' hemodynamic parameters but also greatly improved intubation conditions.
摘要：
未经授权：低剂量麻黄碱和氯胺酮可能会加速神经肌肉阻断剂的起效时间。我们研究了麻黄碱，氯胺酮和顺式阿曲库铵引发对气管插管条件和顺式阿曲库铵起效时间的影响。
UNASSIGNED：该研究是对美国麻醉医师协会（ASA）1级和2级患者进行的双盲临床试验，他们是全身麻醉的候选人。总的来说,120例患者进入研究，分为4组，E,K,E+K,第一组给予70微克/千克麻黄碱(E组)，第二组给予0.5ml/kg氯胺酮（K组），第三组给予相同量的氯胺酮加麻黄碱（E+K组），第四组给予相同体积的生理盐水(对照组);给予单剂量0.1mg/kg顺式阿曲库铵,和插管条件在顺式阿曲库铵给药后60秒进行评估。
UNASSIGNED：基于对喉镜检查反应的平均Cooper评分，声带的位置，而对照组患者膈肌运动均值为2.53±1.07,明显低于三组E,K,和E+K，均值为4.47。分别为1.17、4.53±1.14和7.63±1.42（P值<0.001）。在(E+K)组中，显着高于单独使用其他两种药物（P值<0.001）。单纯E、K两组间差异无统计学意义(P值=0.997)。各组血流动力学参数均值无显著差异(P值>0.05)。
未经授权：根据本研究的结果，单独使用低剂量麻黄碱和氯胺酮可以改善插管条件。此外,这些药物的联合使用不仅对患者的血流动力学参数有积极影响，而且极大地改善了插管条件。
UNASSIGNED：该研究是对美国麻醉医师协会（ASA）1级和2级患者进行的双盲临床试验，他们是全身麻醉的候选人。总的来说,120例患者进入研究，分为4组，E,K,E+K,第一组给予70微克/千克麻黄碱(E组)，第二组给予0.5ml/kg氯胺酮（K组），第三组给予相同量的氯胺酮加麻黄碱（E+K组），第四组给予相同体积的生理盐水(对照组);给予单剂量0.1mg/kg顺式阿曲库铵,和插管条件在顺式阿曲库铵给药后60秒进行评估。
UNASSIGNED：基于对喉镜检查反应的平均Cooper评分，声带的位置，而对照组患者膈肌运动均值为2.53±1.07,明显低于三组E,K,和E+K，均值为4.47。分别为1.17、4.53±1.14和7.63±1.42（P值<0.001）。在(E+K)组中，显着高于单独使用其他两种药物（P值<0.001）。单纯E、K两组间差异无统计学意义(P值=0.997)。各组血流动力学参数均值无显著差异(P值>0.05)。
未经授权：根据本研究的结果，单独使用低剂量麻黄碱和氯胺酮可以改善插管条件。此外,这些药物的联合使用不仅对患者的血流动力学参数有积极影响，而且极大地改善了插管条件。
