PDF(Pubmed)
Abstract：
Previously, a single source of progenitor cells was thought to be responsible for the formation of the cardiac muscle. However, the second heart field has recently been identified as an additional source of myocardial progenitor cells. The chicken embryo, which develops in the egg, outside the mother can easily be manipulated in vivo and in vitro. Hence, it was an excellent model for establishing the concept of the second heart field. Here, our review will focus on the chicken model, specifically its role in understanding the second heart field. In addition to discussing historical aspects, we provide an overview of recent findings that have helped to define the chicken second heart field progenitor cells. A better understanding of the second heart field development will provide important insights into the congenital malformations affecting cardiac muscle formation and function.
摘要：
以前,祖细胞的单一来源被认为是心肌形成的原因。然而,第二心脏区域最近被确定为心肌祖细胞的额外来源。鸡的胚胎,在卵中发育，在体外的母亲可以很容易地在体内和体外操作。因此，这是建立第二心场概念的绝佳模型。这里,我们的审查将集中在鸡的模型，特别是它在理解第二心脏领域中的作用。除了讨论历史方面，我们概述了最近的发现，这些发现有助于定义鸡第二心脏区域祖细胞。对第二心脏场发育的更好理解将为影响心肌形成和功能的先天性畸形提供重要见解。
