PDF(Pubmed)
Abstract：
Ralstonia spp. is an emerging, non-fermentative Gram-negative rod that demonstrates multidrug resistance. Herein, four cases of bloodstream infections (BSI) caused by R. mannitolilytica or R. pickettii are presented. All the cases had comorbidities that predisposed them to this opportunistic infection. The microbiological assessment showed carbapenemase genes carried out in two strains with minimal inhibitory concentrations > 32 μg/mL to imipenem and meropenem. Fluoroquinolones and trimethoprim-sulphamethoxazole were the most potent agents showing activity against 3/4 strains (75%), although treatment should be susceptibility-dependent for each strain. This case series highlights the possibility of co-infection by a rare organism during the COVID-19 pandemic and the importance of the readiness of diagnostic laboratories to support the diagnosis of uncommon pathogens.
摘要：
Ralstoniaspp.是一个新兴的，显示多药耐药性的非发酵革兰氏阴性棒。在这里，介绍了4例由甘露醇R.mannitolytica或R.pickettii引起的血流感染（BSI）。所有病例都有合并症，使他们容易受到这种机会性感染。微生物学评估显示碳青霉烯酶基因在对亚胺培南和美罗培南的最小抑制浓度>32μg/mL的两个菌株中进行。氟喹诺酮和甲氧苄啶-磺胺甲恶唑是对3/4菌株（75％）显示活性的最有效的药物，尽管治疗对于每种菌株都应具有易感性依赖性。该病例系列强调了在COVID-19大流行期间罕见生物共同感染的可能性，以及诊断实验室准备支持诊断罕见病原体的重要性。
