PDF(Pubmed)
Abstract：
Obesity is associated with an increased risk of acute kidney injury (AKI) after trauma. However, the associations between different adipose tissue depots and AKI remain unknown. Our study aimed to quantify the effect of abdominal adiposity on AKI in trauma patients.
We performed a retrospective cohort study of abdominal trauma patients who were admitted to our hospital from January 2010 to March 2020. Abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured at the level of the third lumbar vertebra using computed tomography. Causal modeling based on the generalized propensity score was used to quantify the effects of body mass index (BMI), VAT, and SAT on AKI.
Among 324 abdominal trauma patients, 67 (20.68%) patients developed AKI. Patients with AKI had higher BMI (22.46 kg/m2 vs. 22.04 kg/m2, p = 0.014), higher SAT areas (89.06 cm2 vs. 83.39 cm2, p = 0.151), and higher VAT areas (140.02 cm2 vs. 91.48 cm2, p = 0.001) than those without AKI. By using causal modeling, we found that the risk of developing AKI increased by 8.3% (p = 0.001) and 4.8% (p = 0.022) with one unit increase in BMI (per 1 kg/m2) and ten units increase in SAT (per 10 cm2), respectively. However, VAT did not show a significant association with AKI (p = 0.327).
SAT, but not VAT, increased the risk of AKI among abdominal trauma patients. Measurement of SAT might help identify patients at higher risk of AKI.
We performed a retrospective cohort study of abdominal trauma patients who were admitted to our hospital from January 2010 to March 2020. Abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were measured at the level of the third lumbar vertebra using computed tomography. Causal modeling based on the generalized propensity score was used to quantify the effects of body mass index (BMI), VAT, and SAT on AKI.
Among 324 abdominal trauma patients, 67 (20.68%) patients developed AKI. Patients with AKI had higher BMI (22.46 kg/m2 vs. 22.04 kg/m2, p = 0.014), higher SAT areas (89.06 cm2 vs. 83.39 cm2, p = 0.151), and higher VAT areas (140.02 cm2 vs. 91.48 cm2, p = 0.001) than those without AKI. By using causal modeling, we found that the risk of developing AKI increased by 8.3% (p = 0.001) and 4.8% (p = 0.022) with one unit increase in BMI (per 1 kg/m2) and ten units increase in SAT (per 10 cm2), respectively. However, VAT did not show a significant association with AKI (p = 0.327).
SAT, but not VAT, increased the risk of AKI among abdominal trauma patients. Measurement of SAT might help identify patients at higher risk of AKI.
摘要：
背景：肥胖与创伤后急性肾损伤（AKI）的风险增加有关。然而,不同脂肪组织储库与AKI之间的关联尚不清楚.我们的研究旨在量化腹部肥胖对创伤患者AKI的影响。
方法：我们对2010年1月至2020年3月我院收治的腹部创伤患者进行了回顾性队列研究。使用计算机断层扫描在第三腰椎水平测量腹部内脏脂肪组织（VAT）和皮下脂肪组织（SAT）。基于广义倾向评分的因果模型用于量化体重指数（BMI）的影响，VAT,SAT在AKI上。
结果：在324例腹部创伤患者中，67例（20.68%）患者发生AKI。AKI患者的BMI较高（22.46kg/m2vs.22.04kg/m2,p=0.014),较高的SAT面积（89.06cm2与83.39cm2,p=0.151),和更高的增值税面积(140.02cm2与91.48cm2，p=0.001）比没有AKI的那些。通过使用因果建模，我们发现，发生AKI的风险增加了8.3％（p=0.001）和4.8％（p=0.022），BMI增加了一个单位（每1kg/m2），SAT增加了十个单位（每10cm2），分别。然而,VAT与AKI没有显着关联（p=0.327）。
结论：SAT，但不是增值税，增加了腹部创伤患者发生AKI的风险。SAT的测量可能有助于识别AKI风险较高的患者。
方法：我们对2010年1月至2020年3月我院收治的腹部创伤患者进行了回顾性队列研究。使用计算机断层扫描在第三腰椎水平测量腹部内脏脂肪组织（VAT）和皮下脂肪组织（SAT）。基于广义倾向评分的因果模型用于量化体重指数（BMI）的影响，VAT,SAT在AKI上。
结果：在324例腹部创伤患者中，67例（20.68%）患者发生AKI。AKI患者的BMI较高（22.46kg/m2vs.22.04kg/m2,p=0.014),较高的SAT面积（89.06cm2与83.39cm2,p=0.151),和更高的增值税面积(140.02cm2与91.48cm2，p=0.001）比没有AKI的那些。通过使用因果建模，我们发现，发生AKI的风险增加了8.3％（p=0.001）和4.8％（p=0.022），BMI增加了一个单位（每1kg/m2），SAT增加了十个单位（每10cm2），分别。然而,VAT与AKI没有显着关联（p=0.327）。
结论：SAT，但不是增值税，增加了腹部创伤患者发生AKI的风险。SAT的测量可能有助于识别AKI风险较高的患者。
