Abstract：
Aim: To characterize extensively drug-resistant Pseudomonas aeruginosa from a patient with diarrhea. Materials & methods: Antimicrobial susceptibility was tested by the disk diffusion method. The P. aeruginosa genome was sequenced to identify virulence, antibiotic resistance and prophages encoding genes. Results: P. aeruginosa had a wide spectrum of resistance to antibiotics. Genomic analysis of P. aeruginosa revealed 76 genes associated with antimicrobial resistance, xenobiotic degradation and the type three secretion system. Conclusion: This is the first report on diarrhea associated with P. aeruginosa. Since no other organism was identified, the authors assume that the patient had dysbiosis due to antibiotic exposure, leading to antibiotic-associated diarrhea. The in vivo toxicity expressed by the pathogen may be associated with T3SS.
摘要：
目的：从腹泻患者中鉴定广泛耐药的铜绿假单胞菌。材料和方法:通过圆盘扩散法测试抗微生物敏感性。对铜绿假单胞菌基因组进行测序以鉴定毒力，抗生素抗性和噬菌体编码基因。结果：铜绿假单胞菌对抗生素具有广泛的耐药性。铜绿假单胞菌的基因组分析揭示了76个与抗菌素耐药性相关的基因，异种生物降解和三型分泌系统。结论:本研究首次报道铜绿假单胞菌相关性腹泻。由于没有发现其他生物，作者假设患者因接触抗生素而出现菌群失调，导致抗生素相关性腹泻。病原体表达的体内毒性可能与T3SS有关。
