Abstract：
Mechanical ventilation is an advanced life support treatment for patients with acute respiratory failure. While stabilizing respiratory function, it also acts as an injury factor to exacerbate or lead to lung injury, that is, ventilation-induced lung injury (VILI). There may be a more subtle form of damage to VILI known as \"biotrauma\". However, the mechanism of biotrauma in VILI is still unclear. This article intends to review the mechanism of biotrauma of VILI from the aspects of inflammatory response, oxidative stress and complement activation, in order to provide a new strategy for clinical prevention and treatment of biotrauma caused by VILI.
摘要：
机械通气是急性呼吸衰竭患者的高级生命支持治疗。在稳定呼吸功能的同时，它也是一种伤害因素，加剧或导致肺损伤，也就是说,通气诱导的肺损伤（VILI）。VILI可能有一种更微妙的损害形式，称为“生物创伤”。然而,VILI中生物创伤的机制尚不清楚。本文拟从炎症反应方面对VILI的生物损伤机制进行综述,氧化应激和补体激活，以期为临床预防和治疗VILI引起的生物创伤提供新的策略。
