PDF(Pubmed)
Abstract：
UNASSIGNED: Seizure control among children with epilepsy (CWE) receiving anti-seizure medications (ASMs) remains a challenge in low-resource settings. Uncontrolled seizures are significantly associated with increased morbidity and mortality among CWE. This negatively impacts their quality of life and increases stigma.
UNASSIGNED: This study determined seizure control status and described the factors associated among CWE receiving ASMs at Mbarara Regional Referral Hospital (MRRH).
UNASSIGNED: In a retrospective chart review study, socio-demographic and clinical data were obtained from 112 medical records. CWE receiving ASMs for at least six months and regularly attending the clinic were included in the study. Physical or telephone interviews were conducted with the immediate caregivers of the CWE to establish the current seizure control status of the participants.
UNASSIGNED: A total of 112 participants were enrolled. Of these, three-quarters had generalized onset seizures, 23% had focal onset seizures, while 2% had unknown onset motor seizures. About 60.4% of the study participants had poor seizure control. Having a comorbidity (p-value 0.048, AOR 3.2 (95% CI 1.0-9.9)), history suggestive of birth asphyxia (p-value 0.014, AOR 17.8 (95% CI 1.8-176.8)), and being an adolescent (p-value 0.006, AOR 6.8 (95% CI 1.8-26.6)) were significantly associated with poor seizure control.
UNASSIGNED: Seizure control among CWE receiving ASMs at MRRH remains poor. Efforts geared to addressing seizure control and optimizing drugs are needed, especially among children with comorbidities, those with history of birth asphyxia, and adolescents.
UNASSIGNED: This study determined seizure control status and described the factors associated among CWE receiving ASMs at Mbarara Regional Referral Hospital (MRRH).
UNASSIGNED: In a retrospective chart review study, socio-demographic and clinical data were obtained from 112 medical records. CWE receiving ASMs for at least six months and regularly attending the clinic were included in the study. Physical or telephone interviews were conducted with the immediate caregivers of the CWE to establish the current seizure control status of the participants.
UNASSIGNED: A total of 112 participants were enrolled. Of these, three-quarters had generalized onset seizures, 23% had focal onset seizures, while 2% had unknown onset motor seizures. About 60.4% of the study participants had poor seizure control. Having a comorbidity (p-value 0.048, AOR 3.2 (95% CI 1.0-9.9)), history suggestive of birth asphyxia (p-value 0.014, AOR 17.8 (95% CI 1.8-176.8)), and being an adolescent (p-value 0.006, AOR 6.8 (95% CI 1.8-26.6)) were significantly associated with poor seizure control.
UNASSIGNED: Seizure control among CWE receiving ASMs at MRRH remains poor. Efforts geared to addressing seizure control and optimizing drugs are needed, especially among children with comorbidities, those with history of birth asphyxia, and adolescents.
摘要：
未经评估：在低资源环境下，接受抗癫痫药物（ASM）治疗的癫痫儿童（CWE）的癫痫控制仍然是一个挑战。未控制的癫痫发作与CWE的发病率和死亡率增加显著相关。这对他们的生活质量产生了负面影响，并增加了污名。
UNASSIGNED：本研究确定了在Mbarara地区转诊医院（MRRH）接受ASM的CWE的癫痫发作控制状态，并描述了相关因素。
未经评估：在一项回顾性图表回顾研究中，我们从112份医疗记录中获得了社会人口统计学和临床数据.CWE接受ASM至少6个月并定期到诊所就诊被纳入研究。与CWE的直接护理人员进行了身体或电话访谈，以确定参与者的当前癫痫发作控制状态。
UNASSIGNED：共有112名参与者参加。其中,四分之三的人有全身性发作，23%的人有局灶性癫痫发作，而2%有未知发作的运动性癫痫发作。约60.4%的研究参与者癫痫发作控制不佳。具有合并症(p值0.048，AOR3.2(95%CI1.0-9.9))，提示出生窒息的病史（p值0.014，AOR17.8（95％CI1.8-176.8）），青少年(p值0.006,AOR6.8(95%CI1.8-26.6))与癫痫发作控制不良显著相关.
未经评估：在MRRH接受ASM的CWE中癫痫发作控制仍然很差。需要努力控制癫痫发作和优化药物，尤其是在有合并症的儿童中，那些有出生窒息史的人，和青少年。
UNASSIGNED：本研究确定了在Mbarara地区转诊医院（MRRH）接受ASM的CWE的癫痫发作控制状态，并描述了相关因素。
未经评估：在一项回顾性图表回顾研究中，我们从112份医疗记录中获得了社会人口统计学和临床数据.CWE接受ASM至少6个月并定期到诊所就诊被纳入研究。与CWE的直接护理人员进行了身体或电话访谈，以确定参与者的当前癫痫发作控制状态。
UNASSIGNED：共有112名参与者参加。其中,四分之三的人有全身性发作，23%的人有局灶性癫痫发作，而2%有未知发作的运动性癫痫发作。约60.4%的研究参与者癫痫发作控制不佳。具有合并症(p值0.048，AOR3.2(95%CI1.0-9.9))，提示出生窒息的病史（p值0.014，AOR17.8（95％CI1.8-176.8）），青少年(p值0.006,AOR6.8(95%CI1.8-26.6))与癫痫发作控制不良显著相关.
未经评估：在MRRH接受ASM的CWE中癫痫发作控制仍然很差。需要努力控制癫痫发作和优化药物，尤其是在有合并症的儿童中，那些有出生窒息史的人，和青少年。
