Abstract：
Core body temperature (CBT) is a key vital sign and fever is an important indicator of disease. In the past decade, there has been growing interest for vital sign monitoring technology that may be embedded in wearable devices, and the COVID-19 pandemic has highlighted the need for remote patient monitoring systems. While wrist-worn sensors allow continuous assessment of heart rate and oxygen saturation, reliable measurement of CBT at the wrist remains challenging. In this study, CBT was measured continuously in a free-living setting using a novel technology worn at the wrist and compared to reference core body temperature measurements, i.e., CBT values acquired with an ingestible temperature-sensing pill. Fifty individuals who received the COVID-19 booster vaccination were included. The datasets of 33 individuals were used to develop the CBT prediction algorithm, and the algorithm was then validated on the datasets of 17 participants. Mean observation time was 26.4 h and CBT > 38.0 °C occurred in 66% of the participants. CBT predicted by the wrist-worn sensor showed good correlation to the reference CBT (r = 0.72). Bland-Altman statistics showed an average bias of 0.11 °C of CBT predicted by the wrist-worn device compared to reference CBT, and limits of agreement were - 0.67 to + 0.93 °C, which is comparable to the bias and limits of agreement of commonly used tympanic membrane thermometers. The small size of the components needed for this technology would allow its integration into a variety of wearable monitoring systems assessing other vital signs and at the same time allowing maximal freedom of movement to the user.
摘要：
核心体温（CBT）是重要的生命体征，发烧是疾病的重要指标。在过去的十年里,对于可能嵌入在可穿戴设备中的生命体征监测技术，COVID-19大流行凸显了对远程患者监测系统的需求。虽然手腕穿戴式传感器可以连续评估心率和氧饱和度，在手腕CBT的可靠测量仍然具有挑战性。在这项研究中,使用戴在手腕上的新技术在自由生活环境中连续测量CBT，并与参考核心体温测量值进行比较。即，使用可摄取的温度感应药丸获取的CBT值。包括50名接受COVID-19加强疫苗接种的人。33个人的数据集用于开发CBT预测算法，然后在17名参与者的数据集上验证了该算法。平均观察时间为26.4小时，66％的参与者发生CBT>38.0°C。腕上传感器预测的CBT与参考CBT具有良好的相关性（r=0.72）。Bland-Altman统计数据显示，与参考CBT相比，腕戴设备预测的CBT平均偏差为0.11°C。协议限值为-0.67至+0.93°C，这与常用的鼓膜温度计的偏差和一致性极限相当。该技术所需的部件的小尺寸将允许其集成到评估其他生命体征的各种可穿戴监测系统中,并且同时允许用户的最大运动自由度。
