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Abstract：
High profile international goals have been set for the elimination of hepatitis B virus (HBV) infection as a public health threat by the year 2030. Developing and expanding equitable, accessible translational HBV research programmes that represent real-world populations are therefore an urgent priority for clinical and academic communities. We present experiences and insights by an expert interdisciplinary group focusing on barriers that impede adults living with HBV infection from participating in clinical studies. Our viewpoint describes barriers we have identified through working in a variety of settings across South Africa, including lack of education and awareness, experiences of stigma and discrimination, challenges for governance and data management, and a burden of complex morbidity. Through identifying these challenges, we propose solutions and interventions, highlight new approaches, and provide a framework for future research.
摘要：
高调的国际目标已被设定为到2030年消除乙型肝炎病毒（HBV）感染作为公共卫生威胁。发展和扩大公平，因此，代表现实世界人群的可访问的转化HBV研究计划是临床和学术界的当务之急。我们提出的经验和见解，由一个专家跨学科小组侧重于障碍，阻碍生活在乙肝病毒感染的成年人参与临床研究。我们的观点描述了我们通过在南非的各种环境中工作而发现的障碍，包括缺乏教育和意识，耻辱和歧视的经历，治理和数据管理的挑战，和复杂发病率的负担。通过识别这些挑战，我们提出解决方案和干预措施，强调新的方法，并为未来的研究提供框架。
